Metabolic clearance rate of dehydroisoandrosterone sulfate. VII. Effect of lateral versus supine recumbency

T. Singley, J. D. Madden, S. Chand, R. J. Worley, P. C. MacDonald, N. F. Gant

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The physiologic events which may occur with the gravid woman in the supine position suggest that uteroplacental blood flow may be impaired as a consequence of decreased venous return to the heart and the resulting decrease in cardiac output. Since the metabolic clearance rate of dehydroisoandrosterone sulfate (MCR(DS)) previously has been shown to reflect alterations in uteroplacental perfusion, the MCR(DS) was measured in a variety of different obstetric conditions during lateral and supine recumbency. No significant difference in the MCR(DS) was induced by this specific positional change, suggesting that uteroplacental perfusion was not altered. Experimental data are discussed which support this observation, and a possible mechanism for maintenance of uteroplacental blood flow under these circumstances is presented.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalObstetrics and gynecology
Volume47
Issue number4
StatePublished - Dec 1 1976

    Fingerprint

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Singley, T., Madden, J. D., Chand, S., Worley, R. J., MacDonald, P. C., & Gant, N. F. (1976). Metabolic clearance rate of dehydroisoandrosterone sulfate. VII. Effect of lateral versus supine recumbency. Obstetrics and gynecology, 47(4), 419-422.