Metabolic complications of obesity

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

The rising prevalence of obesity is accompanied by an increasing number of patients with the metabolic complications of obesity. The major complications come under the heading of the metabolic syndrome. This syndrome is characterized by plasma lipid disorders (atherogenic dyslipidemia), raised blood pressure, elevated plasma glucose, and a prothrombotic state. The clinical consequences of the metabolic syndrome are coronary heart disease and stroke, type 2 diabetes and its complications, fatty liver, cholesterol gallstones, and possibly some forms of cancer. At the heart of the metabolic syndrome is insulin resistance, which represents a generalized derangement in metabolic processes. Obesity is the predominant factor leading to insulin resistance, although other factors play a role. The mechanistic link between insulin resistance and the metabolic syndrome is complex. The relationship is modulated by yet other factors, such as physical activity, body fat distribution, hormones, and a person's genetic polymorphic architecture. A better understanding of the molecular basis of this relationship is needed to suggest new targets for prevention and treatment of the complications of obesity. In addition, understanding at the clinical level will lead to improved management of these complications.

Original languageEnglish (US)
Pages (from-to)155-165
Number of pages11
JournalEndocrine
Volume13
Issue number2
StatePublished - 2000

Fingerprint

Obesity
Insulin Resistance
Body Fat Distribution
Gallstones
Fatty Liver
Diabetes Complications
Dyslipidemias
Type 2 Diabetes Mellitus
Coronary Disease
Stroke
Cholesterol
Hormones
Exercise
Blood Pressure
Lipids
Glucose
Neoplasms
Therapeutics

Keywords

  • Insulin resistance
  • Metabolic complications
  • Metabolic syndrome
  • Obesity

ASJC Scopus subject areas

  • Endocrinology

Cite this

Metabolic complications of obesity. / Grundy, Scott M.

In: Endocrine, Vol. 13, No. 2, 2000, p. 155-165.

Research output: Contribution to journalArticle

Grundy, SM 2000, 'Metabolic complications of obesity', Endocrine, vol. 13, no. 2, pp. 155-165.
Grundy, Scott M. / Metabolic complications of obesity. In: Endocrine. 2000 ; Vol. 13, No. 2. pp. 155-165.
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