@article{5a75fb0a4bc5425d84538f9f1035c59e,
title = "Metabolic cycles as an underlying basis of biological oscillations",
abstract = "The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the hibernation cycle and the sleep-wake cycle, remain a mystery. We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations.",
author = "Tu, {Benjamin P.} and McKnight, {Steven L.}",
note = "Funding Information: We thank M. Held for help in preparing the figures, and would like to acknowledge funding within the MitoCheck consortium by the European Commission (J.E.) as well as by the Federal Ministry of Education and Research in the framework of the National Genome Research Network (J.E. and R.P.). Funding Information: We thank S. Martin, E. Epperson, P. Franken and R. Greene for valuable input on hibernation and sleep. This work is supported by an NIH grant, an NIH Director{\textquoteright}s Pioneer Award, unrestricted funds from an anonymous donor (S.L.M.), and a Helen Hay Whitney Foundation Postdoctoral Fellowship (B.P.T.).",
year = "2006",
month = sep,
day = "19",
doi = "10.1038/nrm1980",
language = "English (US)",
volume = "7",
pages = "696--701",
journal = "Nature Reviews Molecular Cell Biology",
issn = "1471-0072",
publisher = "Nature Publishing Group",
number = "9",
}