Metabolic differentiation in the embryonic retina

Michalis Agathocleous, Nicola K. Love, Owen Randlett, Julia J. Harris, Jinyue Liu, Andrew J. Murray, William A. Harris

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Unlike healthy adult tissues, cancers produce energy mainly by aerobic glycolysis instead of oxidative phosphorylation. This adaptation, called the Warburg effect, may be a feature of all dividing cells, both normal and cancerous, or it may be specific to cancers. It is not known whether, in a normally growing tissue during development, proliferating and postmitotic cells produce energy in fundamentally different ways. Here we show in the embryonic Xenopus retina in vivo, that dividing progenitor cells depend less on oxidative phosphorylation for ATP production than non-dividing differentiated cells, and instead use glycogen to fuel aerobic glycolysis. The transition from glycolysis to oxidative phosphorylation is connected to the cell differentiation process. Glycolysis is indispensable for progenitor proliferation and biosynthesis, even when it is not used for ATP production. These results suggest that the Warburg effect can be a feature of normal proliferation in vivo, and that the regulation of glycolysis and oxidative phosphorylation is critical for normal development.

Original languageEnglish (US)
Pages (from-to)859-864
Number of pages6
JournalNature Cell Biology
Volume14
Issue number8
DOIs
StatePublished - Aug 1 2012

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Glycolysis
Oxidative Phosphorylation
Retina
Adenosine Triphosphate
Xenopus
Glycogen
Cell Differentiation
Neoplasms
Stem Cells

ASJC Scopus subject areas

  • Cell Biology

Cite this

Agathocleous, M., Love, N. K., Randlett, O., Harris, J. J., Liu, J., Murray, A. J., & Harris, W. A. (2012). Metabolic differentiation in the embryonic retina. Nature Cell Biology, 14(8), 859-864. https://doi.org/10.1038/ncb2531

Metabolic differentiation in the embryonic retina. / Agathocleous, Michalis; Love, Nicola K.; Randlett, Owen; Harris, Julia J.; Liu, Jinyue; Murray, Andrew J.; Harris, William A.

In: Nature Cell Biology, Vol. 14, No. 8, 01.08.2012, p. 859-864.

Research output: Contribution to journalArticle

Agathocleous, M, Love, NK, Randlett, O, Harris, JJ, Liu, J, Murray, AJ & Harris, WA 2012, 'Metabolic differentiation in the embryonic retina', Nature Cell Biology, vol. 14, no. 8, pp. 859-864. https://doi.org/10.1038/ncb2531
Agathocleous M, Love NK, Randlett O, Harris JJ, Liu J, Murray AJ et al. Metabolic differentiation in the embryonic retina. Nature Cell Biology. 2012 Aug 1;14(8):859-864. https://doi.org/10.1038/ncb2531
Agathocleous, Michalis ; Love, Nicola K. ; Randlett, Owen ; Harris, Julia J. ; Liu, Jinyue ; Murray, Andrew J. ; Harris, William A. / Metabolic differentiation in the embryonic retina. In: Nature Cell Biology. 2012 ; Vol. 14, No. 8. pp. 859-864.
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