Metabolic effects of thiazide and 1,25-(OH)2 vitamin D in postmenopausal osteoporosis

K. Sakhaee, A. Zisman, J. R. Poindexter, J. E. Zerwekh, C. Y C Pak

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

It was previously shown that the stimulation of intestinal calcium absorption by exogenous 25-hydroxyvitamin D (25-OHD) in postmenopausal women with osteoporosis was attenuated when thiazide was added, probably due to the suppression of endogenous synthesis of 1,25-(OH)2 vitamin D (1,25-(OH)2D). To test whether the above attenuation could be averted if exogenous 1,25-(OH)2D replaced 25-OHD, 10 women with postmenopausal osteoporosis participated in a three-phase study comprising control (pretreatment), treatment with 1,25-(OH)2D 0.5 μg/day for 4 weeks, and combined 1,25-(OH)2D and trichlormethiazide (TZ) 2 mg/day for 4 weeks. The 1,25-(OH)2D treatment significantly increased serum 1,25-(OH)2D from 60±7.2 (SD) to 154±48 pmol/1, fractional intestinal calcium absorption (α) from 0.386 ±0.055 to 0.613±0.081, and urinary calcium from 3.7±0.8 to 6.6±1.9 mmol/day. Addition of TZ significantly reduced urinary calcium from 6.6±1.9 to 4.8±1.3 mmol/day, without changing α (0.613±0.081 to 0.584±0.070), serum calcium or 1,25-(OH)2D (154±48 to 154±38 pmol/1). Thus, estimated calcium balance (absorbed minus urinary calcium, increased marginally to +5.6 mmol/day on 1,25-(OH)2D alone (p=0.028) and significantly to +6.8 mmol/day on 1,25-(OH)2D+TZ, from the control value of +4.0 mmol/day. Seven patients who were treated long-term with combined 1,25-(OH)2D and TZ for 11-29 months maintained their a (0.593±0.099) and a marginally more positive estimated calcium balance (+6.4 mmol/day, p=0.025 from the control phase). Moreover, there was a stability of bone density of radial shaft, femoral neck, and lumbar spine. In conclusion, when exogenous 1,25-(OH)2D is provided, TZ does not lower serum 1,25-(OH)2D and α in patients with postmenopausal osteoporosis. Thus, the hypocalciuric action of TZ may lead to improved calcium balance and may potentially attenuate further bone loss.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalOsteoporosis International
Volume3
Issue number4
DOIs
StatePublished - Jul 1993

Keywords

  • 1,25-(OH)D
  • Osteoporosis
  • Positive calcium balance
  • Thiazide

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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