Abstract

Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.

Original languageEnglish (US)
Pages (from-to)351-359
Number of pages9
JournalNature Cell Biology
Volume17
Issue number4
DOIs
StatePublished - Apr 30 2015

Fingerprint

Metabolic Networks and Pathways
Cell Survival
Growth
Neoplasms
Biosynthetic Pathways
Oncogenes
Food

ASJC Scopus subject areas

  • Cell Biology

Cite this

Metabolic pathways promoting cancer cell survival and growth. / Boroughs, Lindsey K.; Deberardinis, Ralph J.

In: Nature Cell Biology, Vol. 17, No. 4, 30.04.2015, p. 351-359.

Research output: Contribution to journalArticle

@article{9ebca593a1274e1ca3a42546b5b98a21,
title = "Metabolic pathways promoting cancer cell survival and growth",
abstract = "Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.",
author = "Boroughs, {Lindsey K.} and Deberardinis, {Ralph J.}",
year = "2015",
month = "4",
day = "30",
doi = "10.1038/ncb3124",
language = "English (US)",
volume = "17",
pages = "351--359",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Metabolic pathways promoting cancer cell survival and growth

AU - Boroughs, Lindsey K.

AU - Deberardinis, Ralph J.

PY - 2015/4/30

Y1 - 2015/4/30

N2 - Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.

AB - Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.

UR - http://www.scopus.com/inward/record.url?scp=84925969707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925969707&partnerID=8YFLogxK

U2 - 10.1038/ncb3124

DO - 10.1038/ncb3124

M3 - Article

VL - 17

SP - 351

EP - 359

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 4

ER -