Metabolic pathways promoting cancer cell survival and growth

Lindsey K. Boroughs, Ralph J. Deberardinis

Research output: Contribution to journalReview articlepeer-review

875 Scopus citations


Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.

Original languageEnglish (US)
Pages (from-to)351-359
Number of pages9
JournalNature cell biology
Issue number4
StatePublished - Apr 30 2015

ASJC Scopus subject areas

  • Cell Biology


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