Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications

Grant M. Fischer, Y. N. Vashisht Gopal, Jennifer L. McQuade, Weiyi Peng, Ralph J. DeBerardinis, Michael A. Davies

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Melanomas are metabolically heterogeneous, and they are able to adapt in order to utilize a variety of fuels that facilitate tumor progression and metastasis. The significance of metabolism in melanoma is supported by growing evidence of impact on the efficacy of contemporary therapies for this disease. There are also data to support that the metabolic phenotypes of melanoma cells depend upon contributions from both intrinsic oncogenic pathways and extrinsic factors in the tumor microenvironment. This review summarizes current understanding of the metabolic processes that promote cutaneous melanoma tumorigenesis and progression, the regulation of cancer cell metabolism by the tumor microenvironment, and the impact of metabolic pathways on targeted and immune therapies.

Original languageEnglish (US)
Pages (from-to)11-30
Number of pages20
JournalPigment Cell and Melanoma Research
Volume31
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • glycolysis
  • melanoma
  • metabolism
  • oxidative phosphorylation
  • tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dermatology

Fingerprint Dive into the research topics of 'Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications'. Together they form a unique fingerprint.

  • Cite this