Metabolism of [3-13c]-pyruvate by cysticerci of taenia crassiceps

I. Corbin, R. Simcoff, M. Novak, B. J. Blackburn

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Carbon-13 decoupled 1H spin-echo nuclear magnetic resonance (NMR) spectra, with and without 13C population inversion, of extracts of Taenia crassiceps cysticerci incubated in media containing [3-13C]-pyruvate showed 13C enrichment in alanine, lactate, acetate, succinate, and citrate. Labeling in the latter three metabolites provides substantial evidence that the malic enzyme reaction in this cestode also functions in the direction opposite to that in which it is normally portrayed. The direct passage of pyruvate from the cytosol to the mitochondrion is suggested by the greater percentage of 13C detected in acetate relative to succinate.

Original languageEnglish (US)
Pages (from-to)516-518
Number of pages3
JournalParasitology Research
Volume84
Issue number6
DOIs
StatePublished - 1998

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Taenia crassiceps
Cysticercus
cysticerci
Taenia
Succinic Acid
succinic acid
Pyruvic Acid
Acetates
acetates
metabolism
Cestoda
malic enzyme
enzymatic reactions
cytosol
Citric Acid
citrates
Alanine
Cytosol
alanine
lactates

ASJC Scopus subject areas

  • Parasitology

Cite this

Metabolism of [3-13c]-pyruvate by cysticerci of taenia crassiceps. / Corbin, I.; Simcoff, R.; Novak, M.; Blackburn, B. J.

In: Parasitology Research, Vol. 84, No. 6, 1998, p. 516-518.

Research output: Contribution to journalArticle

Corbin, I. ; Simcoff, R. ; Novak, M. ; Blackburn, B. J. / Metabolism of [3-13c]-pyruvate by cysticerci of taenia crassiceps. In: Parasitology Research. 1998 ; Vol. 84, No. 6. pp. 516-518.
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