Metabolism of catechol estrogen by human erythrocytes

G. W. Bates, C. D. Edman, J. C. Porter, P. C. MacDonald

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone iri vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. Under in vitro conditions, the rate of conversion of 2-hydroxyestrone to 2-methoxyestrone by human RBC’s was such that 7 nmol of 2-methoxyestrone were formed per h per ml of RBC.

Original languageEnglish (US)
Pages (from-to)1120-1123
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume45
Issue number5
DOIs
StatePublished - Nov 1977

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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