Metabolism of catechol estrogen by human erythrocytes

G. W. Bates, C. D. Edman, J. C. Porter, P. C. MacDonald

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone in vivo, evidence was obtained that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. Under in vitro conditions, the rate of conversion of 2-hydroxyestrone to 2-methoxyestrone by human RBC's was such that 7 nmol of 2-methoxyestrone were formed per h per ml of RBC.

Original languageEnglish (US)
Pages (from-to)1120-1123
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume45
Issue number5
StatePublished - 1977

Fingerprint

Catechol Estrogens
Metabolism
Erythrocytes
Blood
Guaiacol
Estrone
Transferases
Cells
Plasmas
Kinetics
Enzymes
2-methoxyestrone
2-hydroxyestrone

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Bates, G. W., Edman, C. D., Porter, J. C., & MacDonald, P. C. (1977). Metabolism of catechol estrogen by human erythrocytes. Journal of Clinical Endocrinology and Metabolism, 45(5), 1120-1123.

Metabolism of catechol estrogen by human erythrocytes. / Bates, G. W.; Edman, C. D.; Porter, J. C.; MacDonald, P. C.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 45, No. 5, 1977, p. 1120-1123.

Research output: Contribution to journalArticle

Bates, GW, Edman, CD, Porter, JC & MacDonald, PC 1977, 'Metabolism of catechol estrogen by human erythrocytes', Journal of Clinical Endocrinology and Metabolism, vol. 45, no. 5, pp. 1120-1123.
Bates GW, Edman CD, Porter JC, MacDonald PC. Metabolism of catechol estrogen by human erythrocytes. Journal of Clinical Endocrinology and Metabolism. 1977;45(5):1120-1123.
Bates, G. W. ; Edman, C. D. ; Porter, J. C. ; MacDonald, P. C. / Metabolism of catechol estrogen by human erythrocytes. In: Journal of Clinical Endocrinology and Metabolism. 1977 ; Vol. 45, No. 5. pp. 1120-1123.
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