Metabolism of H2 and Thy 1 (theta) alloantigens in murine thymocytes

E. S. Vitetta, J. W. Uhr, E. A. Boyse

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Abstract

The metabolism of Thy 1 and H 2 alloantigens was studied in murine thymocytes radiolabeled with 3H precursors or surface radioiodinated. It was found that 125I labeled Thy 1 is rapidly shed from cultured thymocytes, whereas +h 2 alloantigens are not. [3H]galactose labeled Thy 1 is also released from cultured thymocytes, whereas [3H]leucine labeled H 2 alloantigens are not. These results support the concept that H 2 alloantigens are integral macromolecules of the plasma membrane and suggest further that Thy 1 is a peripheral one. Possible mechanisms underlying shedding are discussed.

Original languageEnglish (US)
Pages (from-to)276-282
Number of pages7
JournalEuropean Journal of Immunology
Volume4
Issue number4
Publication statusPublished - 1974

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ASJC Scopus subject areas

  • Immunology

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