The metabolism of Thy 1 and H 2 alloantigens was studied in murine thymocytes radiolabeled with 3H precursors or surface radioiodinated. It was found that 125I labeled Thy 1 is rapidly shed from cultured thymocytes, whereas +h 2 alloantigens are not. [3H]galactose labeled Thy 1 is also released from cultured thymocytes, whereas [3H]leucine labeled H 2 alloantigens are not. These results support the concept that H 2 alloantigens are integral macromolecules of the plasma membrane and suggest further that Thy 1 is a peripheral one. Possible mechanisms underlying shedding are discussed.
|Original language||English (US)|
|Number of pages||7|
|Journal||European Journal of Immunology|
|Publication status||Published - 1974|
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