Metabolism of H‐2 and Thy‐1 (Θ) alloantigens in murine thymocytes

E. S. Vitetta, J. W. Uhr, E. A. Boyse

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The metabolism of Thy‐1 and H‐2 alloantigens was studied in murine thymocytes radiolabeled with 3H precursors or surface radioidinated. It was found that 125I‐labeled Thy‐1 is rapidly shed from cultured thymocytes, whereas H‐2 alloantigens are not. [3H]galactose‐labeled Thy‐1 is also released from cultured thymocytes, whereas [3H]leucine‐labeled H‐2 alloantigens are not. These results support the concept that H‐2 alloantigens are integral macromolecules of the plasma membrane and suggest further that Thy‐1 is a peripheral one. Possible mechanisms underlying shedding are discussed.

Original languageEnglish (US)
Pages (from-to)276-282
Number of pages7
JournalEuropean Journal of Immunology
Volume4
Issue number4
DOIs
StatePublished - Apr 1974

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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