The metabolism of Thy‐1 and H‐2 alloantigens was studied in murine thymocytes radiolabeled with 3H precursors or surface radioidinated. It was found that 125I‐labeled Thy‐1 is rapidly shed from cultured thymocytes, whereas H‐2 alloantigens are not. [3H]galactose‐labeled Thy‐1 is also released from cultured thymocytes, whereas [3H]leucine‐labeled H‐2 alloantigens are not. These results support the concept that H‐2 alloantigens are integral macromolecules of the plasma membrane and suggest further that Thy‐1 is a peripheral one. Possible mechanisms underlying shedding are discussed.
ASJC Scopus subject areas
- Immunology and Allergy