Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): Role of ketone bodies

Tsutomu Nakagawa, Qiang Ge, Robert Pawlosky, R. Max Wynn, Richard L. Veech, Kosaku Uyeda

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Background: Starved rat livers contain metabolites, which activate ChREBP and 14-3-3 interactions. Results: βHB and AcAc in the extract stabilize the ChREBP•14-3-3 complex in cytosol and inhibit the ChREBP/importin interactions. Conclusion: Ketone bodies are directly involved in the regulation of the nuclear/cytosol shuttle for ChREBP. Significance: Under starvation, ketone bodies serve as a "low glucose" sensor to inhibit lipogenesis.

Original languageEnglish (US)
Pages (from-to)28358-28367
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
StatePublished - Sep 27 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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