Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): Role of ketone bodies

Tsutomu Nakagawa; Qiang Ge; Robert Pawlosky; R. Max Wynn; Richard L. Veech; Kosaku Uyeda

doi:10.1074/jbc.M113.498550

Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): Role of ketone bodies

Tsutomu Nakagawa, Qiang Ge, Robert Pawlosky, R. Max Wynn, Richard L. Veech, Kosaku Uyeda

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Background: Starved rat livers contain metabolites, which activate ChREBP and 14-3-3 interactions. Results: βHB and AcAc in the extract stabilize the ChREBP•14-3-3 complex in cytosol and inhibit the ChREBP/importin interactions. Conclusion: Ketone bodies are directly involved in the regulation of the nuclear/cytosol shuttle for ChREBP. Significance: Under starvation, ketone bodies serve as a "low glucose" sensor to inhibit lipogenesis.

Original language	English (US)
Pages (from-to)	28358-28367
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	39
DOIs	https://doi.org/10.1074/jbc.M113.498550
State	Published - Sep 27 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M113.498550

Cite this

@article{8509523b45ae46bfb289f766622bd54c,

title = "Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): Role of ketone bodies",

abstract = "Background: Starved rat livers contain metabolites, which activate ChREBP and 14-3-3 interactions. Results: βHB and AcAc in the extract stabilize the ChREBP•14-3-3 complex in cytosol and inhibit the ChREBP/importin interactions. Conclusion: Ketone bodies are directly involved in the regulation of the nuclear/cytosol shuttle for ChREBP. Significance: Under starvation, ketone bodies serve as a {"}low glucose{"} sensor to inhibit lipogenesis.",

author = "Tsutomu Nakagawa and Qiang Ge and Robert Pawlosky and Wynn, {R. Max} and Veech, {Richard L.} and Kosaku Uyeda",

year = "2013",

month = sep,

day = "27",

doi = "10.1074/jbc.M113.498550",

language = "English (US)",

volume = "288",

pages = "28358--28367",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "39",

}

TY - JOUR

T1 - Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP)

T2 - Role of ketone bodies

AU - Nakagawa, Tsutomu

AU - Ge, Qiang

AU - Pawlosky, Robert

AU - Wynn, R. Max

AU - Veech, Richard L.

AU - Uyeda, Kosaku

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Background: Starved rat livers contain metabolites, which activate ChREBP and 14-3-3 interactions. Results: βHB and AcAc in the extract stabilize the ChREBP•14-3-3 complex in cytosol and inhibit the ChREBP/importin interactions. Conclusion: Ketone bodies are directly involved in the regulation of the nuclear/cytosol shuttle for ChREBP. Significance: Under starvation, ketone bodies serve as a "low glucose" sensor to inhibit lipogenesis.

AB - Background: Starved rat livers contain metabolites, which activate ChREBP and 14-3-3 interactions. Results: βHB and AcAc in the extract stabilize the ChREBP•14-3-3 complex in cytosol and inhibit the ChREBP/importin interactions. Conclusion: Ketone bodies are directly involved in the regulation of the nuclear/cytosol shuttle for ChREBP. Significance: Under starvation, ketone bodies serve as a "low glucose" sensor to inhibit lipogenesis.

UR - http://www.scopus.com/inward/record.url?scp=84884742752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884742752&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.498550

DO - 10.1074/jbc.M113.498550

M3 - Article

C2 - 23918932

AN - SCOPUS:84884742752

SN - 0021-9258

VL - 288

SP - 28358

EP - 28367

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 39

ER -

Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): Role of ketone bodies

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this