Metal-catalyzed regioselective oxy-functionalization of internal alkynes: An entry into ketones, acetals, and spiroketals

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185 Scopus citations

Abstract

(Chemical Equation Presented) Platinum(II) and an unusual cationic gold(I) complex were identified as mild catalysts for the room temperature cycloisomerization or tandem hydroalkoxylation/acetal formation of unactivated internal alkynols. Under the appropriate conditions, 5-endo, 5-exo, 6-endo, and 6-exo cycloisomerization modes are all available.

Original languageEnglish (US)
Pages (from-to)4907-4910
Number of pages4
JournalOrganic Letters
Volume8
Issue number21
DOIs
StatePublished - Oct 12 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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