Metal chelating crosslinkers form nanogels with high chelation stability

Jacques Lux, Minnie Chan, Luce Vander Elst, Eric Schopf, Enas Mahmoud, Sophie Laurent, Adah Almutairi

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

We present a series of hydrogel nanoparticles (nanogels) incorporating either acyclic or cyclic gadolinium chelates as crosslinkers. These crosslinkers are used to formulate polyacrylamide-based nanogels (diameter 50 to 85 nm) yielding contrast agents with enhanced relaxivities (up to 6-fold greater than Dotarem®), because the nanogel structure slows the chelator's tumbling frequency and allows fast water exchange. Importantly, these nanogels also stabilize Gd3+ within the chelator thermodynamically and kinetically against metal displacement through transmetallation, which should reduce toxicity associated with release of free Gd3+. This chelation stability suggests that the chelate crosslinker strategy may prove useful for other applications of metal-chelating nanoparticles in medicine, including other imaging modalities and radiotherapy.

Original languageEnglish (US)
Pages (from-to)6359-6364
Number of pages6
JournalJournal of Materials Chemistry B
Volume1
Issue number46
DOIs
StatePublished - Dec 14 2013

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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    Lux, J., Chan, M., Vander Elst, L., Schopf, E., Mahmoud, E., Laurent, S., & Almutairi, A. (2013). Metal chelating crosslinkers form nanogels with high chelation stability. Journal of Materials Chemistry B, 1(46), 6359-6364. https://doi.org/10.1039/c3tb21104e