Metal Import through Microbial Membranes

Andrew D. Ferguson, Johann Deisenhofer

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Transport systems of Gram-negative bacteria coordinate the passage of metabolites through the outer membrane, periplasm, and the cytoplasmic membrane without compromising the protective properties of the cell envelope. Active transporters orchestrate the import of metals against concentration gradients. These thermodynamically unfavorable processes are coupled to both an electrochemical proton gradient and the hydrolysis of ATP. Crystallographic structures of transport proteins now define in molecular detail most components of an active metal import pathway from Escherichia coli.

Original languageEnglish (US)
Pages (from-to)15-24
Number of pages10
JournalCell
Volume116
Issue number1
DOIs
StatePublished - Jan 9 2004

Fingerprint

Metals
Membranes
Periplasm
Metabolites
Gram-Negative Bacteria
Escherichia coli
Protons
Hydrolysis
Bacteria
Carrier Proteins
Adenosine Triphosphate
Cell Membrane

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Metal Import through Microbial Membranes. / Ferguson, Andrew D.; Deisenhofer, Johann.

In: Cell, Vol. 116, No. 1, 09.01.2004, p. 15-24.

Research output: Contribution to journalArticle

Ferguson, Andrew D. ; Deisenhofer, Johann. / Metal Import through Microbial Membranes. In: Cell. 2004 ; Vol. 116, No. 1. pp. 15-24.
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