Metals inhibit riboflavin-catalyzed generation of superoxide anion in vitro

Lance S. Terada, Jonathan A. Leff, David N. Guidot, Gayle A. Shibao, John E. Repine

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We found that addition of cationic metals inhibited flavin-catalyzed superoxide anion ( {Mathematical expression}) production in vitro. Inhibition of {Mathematical expression} generation by metals appeared to relate to the ability of metal ions to chelate or complex with amine groups, altering their electronegativity. Metal inhibition of {Mathematical expression} production has important implications for biological systems involving {Mathematical expression} radical production, as well as for assays requiring the generation of {Mathematical expression}in vitro.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalInflammation
Volume14
Issue number2
DOIs
StatePublished - Apr 1 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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