Metastasis models for human tumors in athymic mice

useful models for drug development.

D. L. Fine, R. Shoemaker, A. Gazdar, J. G. Mayo, O. Fodstad, M. R. Boyd, B. J. Abbott, P. A. Donovan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Although human tumor xenografts have been extensively used for preclinical evaluation of antitumor agents, most of this work has utilized subcutaneous or subrenal capsule assays based on change in tumor size. To obtain experimental models more reflective of the human clinical situations, we have developed several metastatic models that are based on and complement a panel of cell strains used in large-scale in vitro drug screening. One melanoma and four lung tumors produced metastatic lesions in the lung within 60 days following subcutaneous, intraperitoneal, or intrasplenic inoculation of BALB/C athymic nude mice. Several tumors also produced liver lesions, and one lung tumor strain showed metastasis to the brain. The metastatic lesions histologically resembled the tumors that grew at the inoculation site. In vitro and in vivo cell strains were rederived from the metastatic lesions. These systems may provide practical models for experimental drug and immunotherapeutic trials.

Original languageEnglish (US)
Pages (from-to)291-299
Number of pages9
JournalCancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc
Volume1
StatePublished - 1987

Fingerprint

Nude Mice
Neoplasm Metastasis
Pharmaceutical Preparations
Neoplasms
Lung
Subrenal Capsule Assay
Theoretical Models
Inbred BALB C Mouse
Preclinical Drug Evaluations
Heterografts
Antineoplastic Agents
Melanoma
Liver
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Metastasis models for human tumors in athymic mice : useful models for drug development. / Fine, D. L.; Shoemaker, R.; Gazdar, A.; Mayo, J. G.; Fodstad, O.; Boyd, M. R.; Abbott, B. J.; Donovan, P. A.

In: Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc, Vol. 1, 1987, p. 291-299.

Research output: Contribution to journalArticle

@article{19de9c4e09374d738e5ccbc99357df61,
title = "Metastasis models for human tumors in athymic mice: useful models for drug development.",
abstract = "Although human tumor xenografts have been extensively used for preclinical evaluation of antitumor agents, most of this work has utilized subcutaneous or subrenal capsule assays based on change in tumor size. To obtain experimental models more reflective of the human clinical situations, we have developed several metastatic models that are based on and complement a panel of cell strains used in large-scale in vitro drug screening. One melanoma and four lung tumors produced metastatic lesions in the lung within 60 days following subcutaneous, intraperitoneal, or intrasplenic inoculation of BALB/C athymic nude mice. Several tumors also produced liver lesions, and one lung tumor strain showed metastasis to the brain. The metastatic lesions histologically resembled the tumors that grew at the inoculation site. In vitro and in vivo cell strains were rederived from the metastatic lesions. These systems may provide practical models for experimental drug and immunotherapeutic trials.",
author = "Fine, {D. L.} and R. Shoemaker and A. Gazdar and Mayo, {J. G.} and O. Fodstad and Boyd, {M. R.} and Abbott, {B. J.} and Donovan, {P. A.}",
year = "1987",
language = "English (US)",
volume = "1",
pages = "291--299",
journal = "Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc",
issn = "1043-6995",

}

TY - JOUR

T1 - Metastasis models for human tumors in athymic mice

T2 - useful models for drug development.

AU - Fine, D. L.

AU - Shoemaker, R.

AU - Gazdar, A.

AU - Mayo, J. G.

AU - Fodstad, O.

AU - Boyd, M. R.

AU - Abbott, B. J.

AU - Donovan, P. A.

PY - 1987

Y1 - 1987

N2 - Although human tumor xenografts have been extensively used for preclinical evaluation of antitumor agents, most of this work has utilized subcutaneous or subrenal capsule assays based on change in tumor size. To obtain experimental models more reflective of the human clinical situations, we have developed several metastatic models that are based on and complement a panel of cell strains used in large-scale in vitro drug screening. One melanoma and four lung tumors produced metastatic lesions in the lung within 60 days following subcutaneous, intraperitoneal, or intrasplenic inoculation of BALB/C athymic nude mice. Several tumors also produced liver lesions, and one lung tumor strain showed metastasis to the brain. The metastatic lesions histologically resembled the tumors that grew at the inoculation site. In vitro and in vivo cell strains were rederived from the metastatic lesions. These systems may provide practical models for experimental drug and immunotherapeutic trials.

AB - Although human tumor xenografts have been extensively used for preclinical evaluation of antitumor agents, most of this work has utilized subcutaneous or subrenal capsule assays based on change in tumor size. To obtain experimental models more reflective of the human clinical situations, we have developed several metastatic models that are based on and complement a panel of cell strains used in large-scale in vitro drug screening. One melanoma and four lung tumors produced metastatic lesions in the lung within 60 days following subcutaneous, intraperitoneal, or intrasplenic inoculation of BALB/C athymic nude mice. Several tumors also produced liver lesions, and one lung tumor strain showed metastasis to the brain. The metastatic lesions histologically resembled the tumors that grew at the inoculation site. In vitro and in vivo cell strains were rederived from the metastatic lesions. These systems may provide practical models for experimental drug and immunotherapeutic trials.

UR - http://www.scopus.com/inward/record.url?scp=0023488820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023488820&partnerID=8YFLogxK

M3 - Article

VL - 1

SP - 291

EP - 299

JO - Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc

JF - Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc

SN - 1043-6995

ER -