Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature

Remi A. Kessler, Tomas Garzon-Muvdi, Wuyang Yang, Jon Weingart, Alessandro Olivi, Judy Huang, Henry Brem, Michael Lim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases. Methods Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified. Results We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014. Conclusions We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalWorld Neurosurgery
Volume101
DOIs
StatePublished - May 1 2017
Externally publishedYes

Fingerprint

Meningioma
Neoplasm Metastasis
Proxy
Spine
Radiation
Recurrence
Drug Therapy
Lung
Liver

Keywords

  • Anaplastic
  • Atypical
  • Meningioma
  • Metastasis
  • Resection

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Metastatic Atypical and Anaplastic Meningioma : A Case Series and Review of the Literature. / Kessler, Remi A.; Garzon-Muvdi, Tomas; Yang, Wuyang; Weingart, Jon; Olivi, Alessandro; Huang, Judy; Brem, Henry; Lim, Michael.

In: World Neurosurgery, Vol. 101, 01.05.2017, p. 47-56.

Research output: Contribution to journalArticle

Kessler, Remi A. ; Garzon-Muvdi, Tomas ; Yang, Wuyang ; Weingart, Jon ; Olivi, Alessandro ; Huang, Judy ; Brem, Henry ; Lim, Michael. / Metastatic Atypical and Anaplastic Meningioma : A Case Series and Review of the Literature. In: World Neurosurgery. 2017 ; Vol. 101. pp. 47-56.
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