Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis

Scott M. Dinehart, Paula Nelson-Adesokan, Clay Cockerell, Shelly Russell, Robert Brown

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

BACKGROUND. Squamous cell carcinoma (SCC) with histologically contiguous actinic keratosis has long been thought of as a tumor with minimal risk for metastasis. The objective of this study was to determine if contiguous actinic keratosis is present in the original tumors of metastatic cutaneous SCC and to describe the histologic features of these tumors. METHODS. The primary lesions of 22 patients with metastatic cutaneous SCC were examined using light microscopy. RESULTS. Contiguous actinic keratosis was present histologically in 44% of the original lesions of cutaneous SCC that metastasized. The average tumor thickness was 6.6 mm. Greater than 66% of the tumors were well or moderately differentiated. The skin adjacent to the tumors showed solar degeneration in almost all instances. CONCLUSIONS. The histologic presence of contiguous actinic keratosis is not a useful predictor of the metastatic behavior of cutaneous SCC. Increased tumor thickness and depth of invasion are the most consistent histopathologic features of cutaneous SCC that metastasize.

Original languageEnglish (US)
Pages (from-to)920-923
Number of pages4
JournalCancer
Volume79
Issue number5
DOIs
StatePublished - Mar 1 1997

Fingerprint

Actinic Keratosis
Squamous Cell Carcinoma
Skin
Neoplasms
Microscopy
Neoplasm Metastasis
Light

Keywords

  • actinic keratosis
  • metastasis
  • skin
  • solar keratosis
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis. / Dinehart, Scott M.; Nelson-Adesokan, Paula; Cockerell, Clay; Russell, Shelly; Brown, Robert.

In: Cancer, Vol. 79, No. 5, 01.03.1997, p. 920-923.

Research output: Contribution to journalArticle

Dinehart, SM, Nelson-Adesokan, P, Cockerell, C, Russell, S & Brown, R 1997, 'Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis', Cancer, vol. 79, no. 5, pp. 920-923. https://doi.org/10.1002/(SICI)1097-0142(19970301)79:5<920::AID-CNCR8>3.0.CO;2-F
Dinehart, Scott M. ; Nelson-Adesokan, Paula ; Cockerell, Clay ; Russell, Shelly ; Brown, Robert. / Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis. In: Cancer. 1997 ; Vol. 79, No. 5. pp. 920-923.
@article{e35eb6d6e86c4422b7d7ae20ea74641e,
title = "Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis",
abstract = "BACKGROUND. Squamous cell carcinoma (SCC) with histologically contiguous actinic keratosis has long been thought of as a tumor with minimal risk for metastasis. The objective of this study was to determine if contiguous actinic keratosis is present in the original tumors of metastatic cutaneous SCC and to describe the histologic features of these tumors. METHODS. The primary lesions of 22 patients with metastatic cutaneous SCC were examined using light microscopy. RESULTS. Contiguous actinic keratosis was present histologically in 44{\%} of the original lesions of cutaneous SCC that metastasized. The average tumor thickness was 6.6 mm. Greater than 66{\%} of the tumors were well or moderately differentiated. The skin adjacent to the tumors showed solar degeneration in almost all instances. CONCLUSIONS. The histologic presence of contiguous actinic keratosis is not a useful predictor of the metastatic behavior of cutaneous SCC. Increased tumor thickness and depth of invasion are the most consistent histopathologic features of cutaneous SCC that metastasize.",
keywords = "actinic keratosis, metastasis, skin, solar keratosis, squamous cell carcinoma",
author = "Dinehart, {Scott M.} and Paula Nelson-Adesokan and Clay Cockerell and Shelly Russell and Robert Brown",
year = "1997",
month = "3",
day = "1",
doi = "10.1002/(SICI)1097-0142(19970301)79:5<920::AID-CNCR8>3.0.CO;2-F",
language = "English (US)",
volume = "79",
pages = "920--923",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis

AU - Dinehart, Scott M.

AU - Nelson-Adesokan, Paula

AU - Cockerell, Clay

AU - Russell, Shelly

AU - Brown, Robert

PY - 1997/3/1

Y1 - 1997/3/1

N2 - BACKGROUND. Squamous cell carcinoma (SCC) with histologically contiguous actinic keratosis has long been thought of as a tumor with minimal risk for metastasis. The objective of this study was to determine if contiguous actinic keratosis is present in the original tumors of metastatic cutaneous SCC and to describe the histologic features of these tumors. METHODS. The primary lesions of 22 patients with metastatic cutaneous SCC were examined using light microscopy. RESULTS. Contiguous actinic keratosis was present histologically in 44% of the original lesions of cutaneous SCC that metastasized. The average tumor thickness was 6.6 mm. Greater than 66% of the tumors were well or moderately differentiated. The skin adjacent to the tumors showed solar degeneration in almost all instances. CONCLUSIONS. The histologic presence of contiguous actinic keratosis is not a useful predictor of the metastatic behavior of cutaneous SCC. Increased tumor thickness and depth of invasion are the most consistent histopathologic features of cutaneous SCC that metastasize.

AB - BACKGROUND. Squamous cell carcinoma (SCC) with histologically contiguous actinic keratosis has long been thought of as a tumor with minimal risk for metastasis. The objective of this study was to determine if contiguous actinic keratosis is present in the original tumors of metastatic cutaneous SCC and to describe the histologic features of these tumors. METHODS. The primary lesions of 22 patients with metastatic cutaneous SCC were examined using light microscopy. RESULTS. Contiguous actinic keratosis was present histologically in 44% of the original lesions of cutaneous SCC that metastasized. The average tumor thickness was 6.6 mm. Greater than 66% of the tumors were well or moderately differentiated. The skin adjacent to the tumors showed solar degeneration in almost all instances. CONCLUSIONS. The histologic presence of contiguous actinic keratosis is not a useful predictor of the metastatic behavior of cutaneous SCC. Increased tumor thickness and depth of invasion are the most consistent histopathologic features of cutaneous SCC that metastasize.

KW - actinic keratosis

KW - metastasis

KW - skin

KW - solar keratosis

KW - squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0031040178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031040178&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0142(19970301)79:5<920::AID-CNCR8>3.0.CO;2-F

DO - 10.1002/(SICI)1097-0142(19970301)79:5<920::AID-CNCR8>3.0.CO;2-F

M3 - Article

C2 - 9041154

AN - SCOPUS:0031040178

VL - 79

SP - 920

EP - 923

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 5

ER -