TY - JOUR
T1 - Metastatic Ewing's sarcoma
T2 - Remission induction and survival
AU - Hayes, F. A.
AU - Thompson, E. I.
AU - Parvey, L.
AU - Rao, B.
AU - Kun, L.
AU - Parham, D.
AU - Hustu, H. O.
PY - 1987
Y1 - 1987
N2 - Eighteen patients with previously untreated metastatic Ewing's sarcoma (ES) entered a protocol designed to evaluate the response rate to cyclophosphamide and doxorubicin induction therapy delivered before delayed surgery and delayed lower dose, limited-field radiation therapy, (RT), and maintenance chemotherapy. With chemotherapy and delayed surgery, 14 of 18 were rendered free of gross tumor. RT was delivered to the primary site of 11 of these responding patients, plus four of those not free of gross disease. Following RT, two more attained complete clinical remission. Site of primary or metastases did not influence outcome; however, the size of the primary at diagnosis did appear to do so. Ten patients remain disease-free 16 to 82 months (median, 47 months) from diagnosis.
AB - Eighteen patients with previously untreated metastatic Ewing's sarcoma (ES) entered a protocol designed to evaluate the response rate to cyclophosphamide and doxorubicin induction therapy delivered before delayed surgery and delayed lower dose, limited-field radiation therapy, (RT), and maintenance chemotherapy. With chemotherapy and delayed surgery, 14 of 18 were rendered free of gross tumor. RT was delivered to the primary site of 11 of these responding patients, plus four of those not free of gross disease. Following RT, two more attained complete clinical remission. Site of primary or metastases did not influence outcome; however, the size of the primary at diagnosis did appear to do so. Ten patients remain disease-free 16 to 82 months (median, 47 months) from diagnosis.
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U2 - 10.1200/JCO.1987.5.8.1199
DO - 10.1200/JCO.1987.5.8.1199
M3 - Article
C2 - 3625245
AN - SCOPUS:0023574820
SN - 0732-183X
VL - 5
SP - 1199
EP - 1204
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 8
ER -