Metastatic osteosarcoma to the liver after treatment for synovial sarcoma

A case report

Najat C. Daw, Sue C. Kaste, D. Ashley Hill, Larry E. Kun, Charles B. Pratt

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Metastatic osteosarcoma most commonly affects the lungs and other bones. Hepatic metastasis at the lime of diagnosis is extremely rare. A 14-year-old boy with synovial sarcoma of the left popliteal fossa was treated with surgical resection, radiotherapy for microscopic residual disease, and 1 year of chemotherapy (vincristine, cyclophosphamide, dactinomycin, and doxorubicin). Approximately 10 years after the initial diagnosis, a secondary osteosarcoma developed in the left proximal tibia. Computed tomography at presentation showed bilateral pulmonary metastases and large ossified nodules in the liver that demonstrated abnormal avidity on 99mTc MDP bone scan indicating hepatic metastasis. Despite chemotherapy (cisplatin, ifosfamide, high-dose methotrexate, and dacarbazine), the patient died of progressive disease 4 months after the diagnosis of the second cancer. Hepatic metastasis was found at the time of diagnosis of a secondary osteosarcoma and manifested as ossified nodules. The risk of radiation-induced osteosarcoma should always be considered in decisions about treatment for soft-tissue sarcoma.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalPediatric Hematology and Oncology
Volume18
Issue number2
DOIs
StatePublished - Mar 6 2001

Fingerprint

Synovial Sarcoma
Osteosarcoma
Liver
Neoplasm Metastasis
Chemotherapy
Bone
Technetium Tc 99m Medronate
Bone and Bones
Drug Therapy
Lung
Dacarbazine
Ifosfamide
Second Primary Neoplasms
Radiotherapy
Dactinomycin
Vincristine
Therapeutics
Tibia
Methotrexate
Lime

Keywords

  • Liver
  • Metastasis
  • Osteosarcoma
  • Secondary neoplasm
  • Synovial sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology
  • Cancer Research
  • Management of Technology and Innovation

Cite this

Metastatic osteosarcoma to the liver after treatment for synovial sarcoma : A case report. / Daw, Najat C.; Kaste, Sue C.; Hill, D. Ashley; Kun, Larry E.; Pratt, Charles B.

In: Pediatric Hematology and Oncology, Vol. 18, No. 2, 06.03.2001, p. 123-128.

Research output: Contribution to journalArticle

Daw, Najat C. ; Kaste, Sue C. ; Hill, D. Ashley ; Kun, Larry E. ; Pratt, Charles B. / Metastatic osteosarcoma to the liver after treatment for synovial sarcoma : A case report. In: Pediatric Hematology and Oncology. 2001 ; Vol. 18, No. 2. pp. 123-128.
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