Metastatic squamous cell carcinoma of the vulva to the lung confirmed with allelotyping

Shelly M. Seward, Debra L. Richardson, Marino E. Leon, Weiqiang Zhao, David E. Cohn, Charles L. Hitchcock

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A squamous-cell carcinoma (SCC) of the lung can be indistinguishable from metastatic SCC of gynecologic origin using common histopathologic techniques; however, establishing tumor origin can be clinically relevant. A patient with a Bartholin gland SCC was found to also have a pulmonary SCC, concerning for metastasis versus synchronous pulmonary primary. Hematoxylin and eosin and immunohistochemistry alone could not differentiate the lesion, and both tumors were human papilloma virus positive. Allelotyping for loss of heterozygosity established the pulmonary lesion as a rare event of vulvar pulmonary metastasis. The patient received palliative chemotherapy instead of curative treatment. Allelotyping for loss of heterozygosity is an effective tool to establish metastasis versus synchronous primary tumors in the presence of multiple lesions, helping to direct appropriate clinical management.

Original languageEnglish (US)
Pages (from-to)497-501
Number of pages5
JournalInternational Journal of Gynecological Pathology
Volume28
Issue number5
DOIs
StatePublished - Sep 1 2009

Keywords

  • Allelotyping
  • Bartholin gland
  • HPV
  • Loss of heterozygosity
  • Squamous cell carcinoma
  • Vulvar

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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