Method for MRI-guided conformal thermal therapy of prostate with planar transurethral ultrasound heating applicators

Rajiv Chopra, Mathieu Burtnyk, Masoom A. Haider, Michael J. Bronskill

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

A method for conformal prostate thermal therapy using transurethral ultrasound heating applicators incorporating planar transducers is described. The capability to shape heating patterns to the geometry of the prostate gland from a single element in a multi-element heating applicator was evaluated using Bioheat transfer modelling. Eleven prostate geometries were obtained from patients who underwent MR imaging of the prostate gland prior to radical prostatectomy. Results indicate that ultrasound heating applicators incorporating multi-frequency planar transducers (4 x 20 mm, f = 4.7 MHz, 9.7 MHz) are capable of shaping thermal damage patterns to the geometry of individual prostates. A temperature feedback control algorithm has been developed to control the frequency, rotation rate and applied power level from transurethral heating applicators based on measurements of the boundary temperature during heating. The discrepancy between the thermal damage boundary and the target boundary was less than 5 mm, and the transition distance between coagulation and normal tissue was less than 1 cm. Treatment times for large prostate volumes were less than 50 min, and perfusion did not have significant impact on the control algorithm. Rectal cooling will play an important role in reducing undesired heating near the rectal wall. Experimental validation of the simulations in a tissue-mimicking gel phantom demonstrated good agreement between the predicted and generated patterns of thermal damage.

Original languageEnglish (US)
Pages (from-to)4957-4975
Number of pages19
JournalPhysics in Medicine and Biology
Volume50
Issue number21
DOIs
StatePublished - Nov 7 2005

Fingerprint

Applicators
Magnetic resonance imaging
Heating
Prostate
therapy
Hot Temperature
Ultrasonics
heating
prostate gland
Geometry
damage
Transducers
Therapeutics
transducers
Tissue
geometry
Electric heating elements
Temperature
Coagulation
Temperature control

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Method for MRI-guided conformal thermal therapy of prostate with planar transurethral ultrasound heating applicators. / Chopra, Rajiv; Burtnyk, Mathieu; Haider, Masoom A.; Bronskill, Michael J.

In: Physics in Medicine and Biology, Vol. 50, No. 21, 07.11.2005, p. 4957-4975.

Research output: Contribution to journalArticle

Chopra, Rajiv ; Burtnyk, Mathieu ; Haider, Masoom A. ; Bronskill, Michael J. / Method for MRI-guided conformal thermal therapy of prostate with planar transurethral ultrasound heating applicators. In: Physics in Medicine and Biology. 2005 ; Vol. 50, No. 21. pp. 4957-4975.
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