Methyl Carboxymethylenation of Alcohols via Dehydrative Alkylation

Jurong Yu, Jing Yu Lai, J. R. Falck

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Dehydrative alkylation of alcohols with methyl phenylsulfonylacetate under modified Mitsunobu conditions followed by desulfonylation using magnesium affords two-carbon elongated methyl carboxylates in good to excellent yields. Diols and bromoalcohols furnish cycloalkylcarboxylates.

Original languageEnglish (US)
Pages (from-to)1127-1128
Number of pages2
JournalSynlett
Volume1995
Issue number11
DOIs
StatePublished - Nov 1995

Keywords

  • C-C bond formation
  • Mitsunobu
  • carboxylation
  • desulfonylation

ASJC Scopus subject areas

  • Organic Chemistry

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