Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer

Makoto Suzuki; Hisayuki Shigematsu; Narayan Shivapurkar; Jyotsna Reddy; Kuniharu Miyajima; Takao Takahashi; Adi F. Gazdar; Eugene P. Frenkel

doi:10.1016/j.canlet.2005.11.002

Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer

Makoto Suzuki, Hisayuki Shigematsu, Narayan Shivapurkar, Jyotsna Reddy, Kuniharu Miyajima, Takao Takahashi, Adi F. Gazdar, Eugene P. Frenkel

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

We investigated aberrant methylation in 101 prostate cancers(PCa) and 32 histologically normal prostate tissues. We focused on genes largely in the apoptotic pathway. Methylation frequencies of the genes were Reprimo, 54%; TMS1, 47%; DcR1, 45%; RRAD, 37%; DcR2, 37%; CRBP1, 34%; HPP1, 32%; RIZ1, 31%; DRM/Gremlin, 21%; SOCS1, 20%; DR4, 5%; DR5, 1%. Methylation of Reprimo and TMS1 correlate with preoperative serum prostate-specific antigen. Methylation of TMS1, DcR1, DcR2, and CRBP1 correlate with Gleason score. Methylation of TMS1 and unmethylation of both DcR1 and DcR2 correlate with poorer disease free survival by univariate and multivariate analyses. Our data suggest that methylation of multiple genes may be involved in pathogenesis and correlate with prognosis of PCa.

Original language	English (US)
Pages (from-to)	222-230
Number of pages	9
Journal	Cancer Letters
Volume	242
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2005.11.002
State	Published - Oct 28 2006

Keywords

Methylation
Profile
Prostate cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2005.11.002

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title = "Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer",

abstract = "We investigated aberrant methylation in 101 prostate cancers(PCa) and 32 histologically normal prostate tissues. We focused on genes largely in the apoptotic pathway. Methylation frequencies of the genes were Reprimo, 54%; TMS1, 47%; DcR1, 45%; RRAD, 37%; DcR2, 37%; CRBP1, 34%; HPP1, 32%; RIZ1, 31%; DRM/Gremlin, 21%; SOCS1, 20%; DR4, 5%; DR5, 1%. Methylation of Reprimo and TMS1 correlate with preoperative serum prostate-specific antigen. Methylation of TMS1, DcR1, DcR2, and CRBP1 correlate with Gleason score. Methylation of TMS1 and unmethylation of both DcR1 and DcR2 correlate with poorer disease free survival by univariate and multivariate analyses. Our data suggest that methylation of multiple genes may be involved in pathogenesis and correlate with prognosis of PCa.",

keywords = "Methylation, Profile, Prostate cancer",

author = "Makoto Suzuki and Hisayuki Shigematsu and Narayan Shivapurkar and Jyotsna Reddy and Kuniharu Miyajima and Takao Takahashi and Gazdar, {Adi F.} and Frenkel, {Eugene P.}",

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AU - Suzuki, Makoto

AU - Shigematsu, Hisayuki

AU - Shivapurkar, Narayan

AU - Reddy, Jyotsna

AU - Miyajima, Kuniharu

AU - Takahashi, Takao

AU - Gazdar, Adi F.

AU - Frenkel, Eugene P.

PY - 2006/10/28

Y1 - 2006/10/28

N2 - We investigated aberrant methylation in 101 prostate cancers(PCa) and 32 histologically normal prostate tissues. We focused on genes largely in the apoptotic pathway. Methylation frequencies of the genes were Reprimo, 54%; TMS1, 47%; DcR1, 45%; RRAD, 37%; DcR2, 37%; CRBP1, 34%; HPP1, 32%; RIZ1, 31%; DRM/Gremlin, 21%; SOCS1, 20%; DR4, 5%; DR5, 1%. Methylation of Reprimo and TMS1 correlate with preoperative serum prostate-specific antigen. Methylation of TMS1, DcR1, DcR2, and CRBP1 correlate with Gleason score. Methylation of TMS1 and unmethylation of both DcR1 and DcR2 correlate with poorer disease free survival by univariate and multivariate analyses. Our data suggest that methylation of multiple genes may be involved in pathogenesis and correlate with prognosis of PCa.

AB - We investigated aberrant methylation in 101 prostate cancers(PCa) and 32 histologically normal prostate tissues. We focused on genes largely in the apoptotic pathway. Methylation frequencies of the genes were Reprimo, 54%; TMS1, 47%; DcR1, 45%; RRAD, 37%; DcR2, 37%; CRBP1, 34%; HPP1, 32%; RIZ1, 31%; DRM/Gremlin, 21%; SOCS1, 20%; DR4, 5%; DR5, 1%. Methylation of Reprimo and TMS1 correlate with preoperative serum prostate-specific antigen. Methylation of TMS1, DcR1, DcR2, and CRBP1 correlate with Gleason score. Methylation of TMS1 and unmethylation of both DcR1 and DcR2 correlate with poorer disease free survival by univariate and multivariate analyses. Our data suggest that methylation of multiple genes may be involved in pathogenesis and correlate with prognosis of PCa.

KW - Methylation

KW - Profile

KW - Prostate cancer

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Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer

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Keywords

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