Methylotroph infections and chronic granulomatous disease

E. Liana Falcone, Jennifer R. Petts, Mary Beth Fasano, Bradley Ford, William M. Nauseef, João Farela Neves, Maria João Simões, Millard L. Tierce, M. Teresa De La Morena, David E. Greenberg, Christa S. Zerbe, Adrian M. Zelazny, Steven M. Holland

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by a defect in production of phagocytederived reactive oxygen species, which leads to recurrent infections with a characteristic group of pathogens not previously known to include methylotrophs. Methylotrophs are versatile environmental bacteria that can use single-carbon organic compounds as their sole source of energy; they rarely cause disease in immunocompetent persons. We have identified 12 infections with methylotrophs (5 reported here, 7 previously reported) in patients with CGD. Methylotrophs identified were Granulibacter bethesdensis (9 cases), Acidomonas methanolica (2 cases), and Methylobacterium lusitanum (1 case). Two patients in Europe died; the other 10, from North and Central America, recovered after prolonged courses of antimicrobial drug therapy and, for some, surgery. Methylotrophs are emerging as diseasecausing organisms in patients with CGD. For all patients, sequencing of the 16S rRNA gene was required for correct diagnosis. Geographic origin of the methylotroph strain may affect clinical management and prognosis.

Original languageEnglish (US)
Pages (from-to)404-409
Number of pages6
JournalEmerging Infectious Diseases
Volume22
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Chronic Granulomatous Disease
Infection
Methylobacterium
Central America
North America
rRNA Genes
Reactive Oxygen Species
Carbon
Bacteria
Drug Therapy

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Falcone, E. L., Petts, J. R., Fasano, M. B., Ford, B., Nauseef, W. M., Neves, J. F., ... Holland, S. M. (2016). Methylotroph infections and chronic granulomatous disease. Emerging Infectious Diseases, 22(3), 404-409. https://doi.org/10.3201/eid2203.151265

Methylotroph infections and chronic granulomatous disease. / Falcone, E. Liana; Petts, Jennifer R.; Fasano, Mary Beth; Ford, Bradley; Nauseef, William M.; Neves, João Farela; Simões, Maria João; Tierce, Millard L.; La Morena, M. Teresa De; Greenberg, David E.; Zerbe, Christa S.; Zelazny, Adrian M.; Holland, Steven M.

In: Emerging Infectious Diseases, Vol. 22, No. 3, 01.03.2016, p. 404-409.

Research output: Contribution to journalArticle

Falcone, EL, Petts, JR, Fasano, MB, Ford, B, Nauseef, WM, Neves, JF, Simões, MJ, Tierce, ML, La Morena, MTD, Greenberg, DE, Zerbe, CS, Zelazny, AM & Holland, SM 2016, 'Methylotroph infections and chronic granulomatous disease', Emerging Infectious Diseases, vol. 22, no. 3, pp. 404-409. https://doi.org/10.3201/eid2203.151265
Falcone EL, Petts JR, Fasano MB, Ford B, Nauseef WM, Neves JF et al. Methylotroph infections and chronic granulomatous disease. Emerging Infectious Diseases. 2016 Mar 1;22(3):404-409. https://doi.org/10.3201/eid2203.151265
Falcone, E. Liana ; Petts, Jennifer R. ; Fasano, Mary Beth ; Ford, Bradley ; Nauseef, William M. ; Neves, João Farela ; Simões, Maria João ; Tierce, Millard L. ; La Morena, M. Teresa De ; Greenberg, David E. ; Zerbe, Christa S. ; Zelazny, Adrian M. ; Holland, Steven M. / Methylotroph infections and chronic granulomatous disease. In: Emerging Infectious Diseases. 2016 ; Vol. 22, No. 3. pp. 404-409.
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