Metronidazole, omeprazole and clarithromycin: An effective combination therapy for Helicobacter pylori infection

M. M. Yousfi, H. M T El-Zimaity, M. T. Al-Assi, R. A. Cole, R. M. Genta, D. Y. Graham

Research output: Contribution to journalArticle

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Abstract

Background: Successful treatment of Helicobacter pylori infection results in cure of peptic ulcer disease. Multi-drug regimens are needed to cure this infection. We studied the effectiveness and side effect profile of two antibiotics active against Helicobacter pylori, metronidazole and clarithromycin, combined with omeprazole. Methods: We evaluated a combination therapy for H. pylori infection consisting of metronidazole (500 mg b.d.), omeprazole (20 mg b.d.), and clarithromycin (250 mg b.d.) for 2 weeks, followed by ranitidine 300 mg daily for 4 weeks. Results: Thirty-three patients with documented H. pylori infection were studied. Twenty had previously failed antimicrobial therapy, including one with metronidazole-based triple therapy and eight with macrolide-based therapy (five with clarithromycin-based therapy), and 11 with amoxycillin, tetracycline, and bismuth. H. pylori status was determined by histopathology using the Genta stain and by culture. H. pylori status was determined at entry and 4 weeks after completing antimicrobial therapy. The H. pylori infection was cured in 88% (95% CI = 72%-96%) including 90% of those who had failed previous anti-H. pylori therapies. Mild side effects were reported by 18%. Conclusion: We conclude that the combination of metronidazole, omeprazole and clarithromycin is an effective treatment for H. pylori infection.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalAlimentary Pharmacology and Therapeutics
Volume9
Issue number2
StatePublished - 1995

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Clarithromycin
Omeprazole
Metronidazole
Helicobacter Infections
Helicobacter pylori
Therapeutics
Bismuth
Ranitidine
Amoxicillin
Macrolides
Tetracycline
Peptic Ulcer
Coloring Agents
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Yousfi, M. M., El-Zimaity, H. M. T., Al-Assi, M. T., Cole, R. A., Genta, R. M., & Graham, D. Y. (1995). Metronidazole, omeprazole and clarithromycin: An effective combination therapy for Helicobacter pylori infection. Alimentary Pharmacology and Therapeutics, 9(2), 209-212.

Metronidazole, omeprazole and clarithromycin : An effective combination therapy for Helicobacter pylori infection. / Yousfi, M. M.; El-Zimaity, H. M T; Al-Assi, M. T.; Cole, R. A.; Genta, R. M.; Graham, D. Y.

In: Alimentary Pharmacology and Therapeutics, Vol. 9, No. 2, 1995, p. 209-212.

Research output: Contribution to journalArticle

Yousfi, MM, El-Zimaity, HMT, Al-Assi, MT, Cole, RA, Genta, RM & Graham, DY 1995, 'Metronidazole, omeprazole and clarithromycin: An effective combination therapy for Helicobacter pylori infection', Alimentary Pharmacology and Therapeutics, vol. 9, no. 2, pp. 209-212.
Yousfi, M. M. ; El-Zimaity, H. M T ; Al-Assi, M. T. ; Cole, R. A. ; Genta, R. M. ; Graham, D. Y. / Metronidazole, omeprazole and clarithromycin : An effective combination therapy for Helicobacter pylori infection. In: Alimentary Pharmacology and Therapeutics. 1995 ; Vol. 9, No. 2. pp. 209-212.
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