TY - JOUR
T1 - Metronidazole, omeprazole and clarithromycin
T2 - an effective combination therapy for Helicobacter pylori infection
AU - Yousfi, M. M.
AU - El-Zimaity, H. M T
AU - Al-Assi, M. T.
AU - Cole, R. A.
AU - Genta, R. M.
AU - Graham, D. Y.
PY - 1995/4
Y1 - 1995/4
N2 - Background: Successful treatment of Helicobacter pylori infection results in cure of peptic ulcer disease. Multidrug regimens are needed to cure this infection. We studied the effectiveness and side effect profile of two antibiotics active against Helicobacter pylori, metronidazole and clarithromycin, combined with omeprazole. Methods: We evaluated a combination therapy for H. pylori infection consisting of metronidazole (500 mg b.d.), omeprazole (20 mg b.d.), and clarithromycin (250 mg b.d.) for 2 weeks, followed by ranitidine 300 mg daily for 4 weeks. Results: Thirty‐three patients with documented H. pylori infection were studied. Twenty had previously failed antimicrobial therapy, including one with metronidazole‐based triple therapy and eight with macrolide‐based therapy (five with clarithromycinbased therapy), and 11 with amoxycillin, tetracycline, and bismuth. H. pylori status was determined by histopathology using the Genta stain and by culture. H. pylori status was determined at entry and 4 weeks after completing antimicrobial therapy. The H. pylori infection was cured in 88% (95% CI = 72%–96%) including 90% of those who had failed previous anti‐H. pylori therapies. Mild side effects were reported by 18%. Conclusion: We conclude that the combination of metronidazole, omeprazole and clarithromycin is an effective treatment for H. pylori infection.
AB - Background: Successful treatment of Helicobacter pylori infection results in cure of peptic ulcer disease. Multidrug regimens are needed to cure this infection. We studied the effectiveness and side effect profile of two antibiotics active against Helicobacter pylori, metronidazole and clarithromycin, combined with omeprazole. Methods: We evaluated a combination therapy for H. pylori infection consisting of metronidazole (500 mg b.d.), omeprazole (20 mg b.d.), and clarithromycin (250 mg b.d.) for 2 weeks, followed by ranitidine 300 mg daily for 4 weeks. Results: Thirty‐three patients with documented H. pylori infection were studied. Twenty had previously failed antimicrobial therapy, including one with metronidazole‐based triple therapy and eight with macrolide‐based therapy (five with clarithromycinbased therapy), and 11 with amoxycillin, tetracycline, and bismuth. H. pylori status was determined by histopathology using the Genta stain and by culture. H. pylori status was determined at entry and 4 weeks after completing antimicrobial therapy. The H. pylori infection was cured in 88% (95% CI = 72%–96%) including 90% of those who had failed previous anti‐H. pylori therapies. Mild side effects were reported by 18%. Conclusion: We conclude that the combination of metronidazole, omeprazole and clarithromycin is an effective treatment for H. pylori infection.
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U2 - 10.1111/j.1365-2036.1995.tb00374.x
DO - 10.1111/j.1365-2036.1995.tb00374.x
M3 - Review article
C2 - 7605865
AN - SCOPUS:0028924556
SN - 0269-2813
VL - 9
SP - 209
EP - 212
JO - Alimentary Pharmacology & Therapeutics
JF - Alimentary Pharmacology & Therapeutics
IS - 2
ER -