Mevalonate metabolism by renal tissue in vitro

Philip Raskin, M. D. Siperstein

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Previous studies have demonstrated that the kidneys rather than the liver play the major role in the in vivo metabolism of circulating mevalonic acid. Kidneys, however, convert mevalonic acid primarily to the precursors of cholesterol, squalene and lanosterol, rather than to cholesterol. Tissue slices from rat and dog renal cortex and medulla and glomeruli and tubules were isolated and the incorporation of 14C labeled mevalonic acid into the nonsaponifiable lipids squalene, lanosterol, and cholesterol was determined in these tissues. The results demonstrate that the renal cortex is the primary site of mevalonic acid metabolism within the kidney and that the glomerulus is responsible for 95% of the mevalonic acid metabolized by the renal cortex. As was the case for the whole kidney, the major metabolites of mevalonate in the glomeruli are squalene and lanosterol.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalJournal of lipid research
Volume15
Issue number1
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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