MICAL redox enzymes and actin remodeling: New links to classical tumorigenic and cancer pathways

Jimok Yoon, Jonathan R. Terman

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

MICAL Redox enzymes have recently emerged as direct regulators of cell shape and motility–working through specific reversible post-translational oxidation of actin to disassemble and remodel the cytoskeleton. Links are also now emerging between MICALs and cancer, including our recent results that regulation of MICAL sensitizes cancer cells to the cancer drug Gleevec. Targeting this new actin regulatory enzyme system may thus provide new therapeutic options for cancer treatment.

Original languageEnglish (US)
Article numbere1384881
JournalMolecular and Cellular Oncology
Volume5
Issue number1
DOIs
StatePublished - Jan 2 2018

Keywords

  • Abl
  • Attraction
  • Chemotropic
  • Growth Factors
  • Kinase
  • Phosphorylation
  • Plexins
  • Post-translational Modification
  • Repulsion
  • Semaphorins

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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