MICAL redox enzymes and actin remodeling: New links to classical tumorigenic and cancer pathways

Jimok Yoon; Jonathan R. Terman

doi:10.1080/23723556.2017.1384881

MICAL redox enzymes and actin remodeling: New links to classical tumorigenic and cancer pathways

Jimok Yoon, Jonathan R. Terman

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

MICAL Redox enzymes have recently emerged as direct regulators of cell shape and motility–working through specific reversible post-translational oxidation of actin to disassemble and remodel the cytoskeleton. Links are also now emerging between MICALs and cancer, including our recent results that regulation of MICAL sensitizes cancer cells to the cancer drug Gleevec. Targeting this new actin regulatory enzyme system may thus provide new therapeutic options for cancer treatment.

Original language	English (US)
Article number	e1384881
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2017.1384881
State	Published - Jan 2 2018

Keywords

Abl
Attraction
Chemotropic
Growth Factors
Kinase
Phosphorylation
Plexins
Post-translational Modification
Repulsion
Semaphorins

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2017.1384881

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abstract = "MICAL Redox enzymes have recently emerged as direct regulators of cell shape and motility–working through specific reversible post-translational oxidation of actin to disassemble and remodel the cytoskeleton. Links are also now emerging between MICALs and cancer, including our recent results that regulation of MICAL sensitizes cancer cells to the cancer drug Gleevec. Targeting this new actin regulatory enzyme system may thus provide new therapeutic options for cancer treatment.",

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AU - Terman, Jonathan R.

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AB - MICAL Redox enzymes have recently emerged as direct regulators of cell shape and motility–working through specific reversible post-translational oxidation of actin to disassemble and remodel the cytoskeleton. Links are also now emerging between MICALs and cancer, including our recent results that regulation of MICAL sensitizes cancer cells to the cancer drug Gleevec. Targeting this new actin regulatory enzyme system may thus provide new therapeutic options for cancer treatment.

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KW - Kinase

KW - Phosphorylation

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KW - Post-translational Modification

KW - Repulsion

KW - Semaphorins

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MICAL redox enzymes and actin remodeling: New links to classical tumorigenic and cancer pathways

Abstract

Keywords

ASJC Scopus subject areas

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