Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer

Lisiane B. Meira, David L. Cheo, Antonio M. Reis, Nanna Claij, Dennis K. Burns, Hein te Riele, Errol C. Friedberg

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Mice defective in the mismatch repair (MMR) gene Msh2 manifest an enhanced predisposition to skin cancer associated with exposure to UVB radiation. This predisposition is further heightened if the mice are additionally defective for the nucleotide excision repair gene Xpc. To test the hypothesis that the predisposition of Msh2 mutant mice to skin cancer reflects a mutator phenotype associated with increased proliferation of skin cells following exposure to UV radiation, Msh2 mutant mice were exposed to the tumor promoter TPA. Such mice showed a robust proliferative response in the skin, but did not manifest evidence of dysplasia or neoplasia. We conclude that the predisposition of Msh2 mice to UVB radiation-induced skin cancer reflects an interaction between the processes of mismatch repair and some other excision repair mode, the exact nature of which remains to be established.

Original languageEnglish (US)
Pages (from-to)929-934
Number of pages6
JournalDNA repair
Volume1
Issue number11
DOIs
StatePublished - Nov 1 2002

Keywords

  • Msh2
  • UVB radiation
  • Xpc

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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