MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

Jonathan R. Friedman, Arnaud Mourier, Justin Yamada, J. Michael McCaffery, Jodi Nunnari

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

The conserved MICOS complex functions as a primary determinant of mitochondrial inner membrane structure. We address the organization and functional roles of MICOS and identify two independent MICOS subcomplexes: Mic27/Mic10/Mic12, whose assembly is dependent on respiratory complexes and the mitochondrial lipid cardiolipin, and Mic60/Mic19, which assembles independent of these factors. Our data suggest that MICOS subcomplexes independently localize to cristae junctions and are connected via Mic19, which functions to regulate subcomplex distribution, and thus, potentially also cristae junction copy number. MICOS subunits have non-redundant functions as the absence of MICOS subcomplexes results in more severe morphological and respiratory growth defects than deletion of single MICOS subunits or subcomplexes. Mitochondrial defects resulting from MICOS loss are caused by misdistribution of respiratory complexes in the inner membrane. Together, our data are consistent with a model where MICOS, mitochondrial lipids and respiratory complexes coordinately build a functional and correctly shaped mitochondrial inner membrane.

Original languageEnglish (US)
Article numbere07739
Pages (from-to)1-61
Number of pages61
JournaleLife
Volume2015
Issue number4
DOIs
StatePublished - Apr 28 2015

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture'. Together they form a unique fingerprint.

Cite this