Micro RNA-19a suppresses IL-10 in peripheral B cells from patients with atherosclerosis

Zhong Qiao Ren, Ning Liu, Kan Zhao

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background and aims The interleukin (IL)-10-production B cells play an important role in the pathogenesis of atherosclerosis (Asro) with unknown mechanism. Micro RNA (miR)-17-92 cluster has strong immune regulatory activities. This study tests a hypothesis that miR-17-92 cluster suppresses IL-10 expression in B cells of Asro patients. Methods Patients with Asro were recruited into this study. Peripheral blood samples were collected from the patients. B cells were isolated from the blood samples and analyzed to elucidate the role of miR-17-92 in the regulation of IL-10 expression. Results Peripheral B cells from patients with Asro show lower levels of IL-10 than that from healthy subjects. The IL-10 expression in the B cells is negatively correlated with the expression of miR-19a in the B cells. The serum levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ and interleukin (IL)-4 in Asro patients were higher than healthy subjects. Exposure to TNF-α or IFN-γ or IL-4 suppressed IL-10 expression in B cells via increasing the expression of miR-19a in B cells, which could be abolished by Inhibition of miR-19a. Conclusions TNF-α or IFN-γ or IL-4 suppresses IL-10 in B cells via up regulating miR-19a expression.

Original languageEnglish (US)
Pages (from-to)86-91
Number of pages6
JournalCytokine
Volume86
DOIs
StatePublished - Oct 1 2016

Keywords

  • Atherosclerosis
  • Interleukin-10
  • Lymphocyte
  • Micro RNA
  • p300

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

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