Micro-SPECT combined with 3-D optical imaging

Edward N. Tsyganov, Pietro P. Antich, Padmakar V. Kulkarni, Ralph P. Mason, Robert W. Parkey, Serguei Y. Seliuonine, Jerry W. Shay, Todd W. Soesbe, Alexander I. Zinchenko

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

A resolution enhanced NaI(Tl)-scintillator micro-SPECT device using a pinhole collimator geometry has been built and tested with small animals. This device was constructed based on a depth-of-interaction (DOI) measurement using a thick scintilator crystal and a position sensitive PMT to measure depth dependent scintillator light profiles. DOI measurement eliminates the parallax error that degrades the high spatial resolution required for small animal imaging. This novel technique for 3-D gamma-ray detection was incorporated into a micro-SPECT device and tested with a 57Co source and 98mTc-MDP in mice. We are now investigating the combination of micro-SPECT with 3-D optical imaging, so that the interaction of different biological aspects can be studied by each technique. A simple application permits a 3-D reconstruction of the animal's skin surface thus enhancing visualization and making possible depth-dependent corrections and a quantitative description of biological processes can be achieved. The combination of micro-SPECT and 3-D optical imaging, including bioluminescence 3-D reconstruction, opens new avenues in multi-modality imaging for biology and medicine.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium Conference Record
EditorsJ.A. Seibert
Pages3275-3279
Number of pages5
Volume5
StatePublished - 2004
Event2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors - Rome, Italy
Duration: Oct 16 2004Oct 22 2004

Other

Other2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors
CountryItaly
CityRome
Period10/16/0410/22/04

Keywords

  • Image Reconstruction
  • Optical Imaging
  • Single Photon Emission Computed Tomography
  • Small Animal Imaging

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering

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