Microangiopathic Hemolytic Anemia Due to Malignancy in Pregnancy

Sarah K. Happe, Amanda C. Zofkie, David B. Nelson

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Microangiopathic disorders during pregnancy remain a diagnostic challenge because these conditions often imitate more common obstetric diseases. CASE: A 31-year-old multigravid woman delivered at term with a postpartum course complicated by laboratory indices consistent with hemolysis, elevated liver enzymes, and low platelet count syndrome. After clinical recovery, she was readmitted 2 weeks after delivery with presumptive pyelonephritis. Persistent hemolysis and worsening thrombocytopenia suggested a diagnosis of thrombotic microangiopathy, which did not respond to plasma exchange. Directed bone biopsy revealed metastatic signet ring cell adenocarcinoma. CONCLUSION: Microangiopathic hemolytic anemia is rarely the initial clinical manifestation of malignancy. Given the similar features of several common obstetric complications, additional diagnostic measures may be necessary to refine the diagnosis in cases unresponsive to standard obstetric management.

Original languageEnglish (US)
Pages (from-to)1437-1440
Number of pages4
JournalObstetrics and Gynecology
Volume128
Issue number6
DOIs
StatePublished - Dec 1 2016

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Hemolytic Anemia
Obstetrics
Hemolysis
Pregnancy
Thrombotic Microangiopathies
Neoplasms
Plasma Exchange
Pyelonephritis
Platelet Count
Thrombocytopenia
Postpartum Period
Adenocarcinoma
Biopsy
Bone and Bones
Liver
Enzymes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Microangiopathic Hemolytic Anemia Due to Malignancy in Pregnancy. / Happe, Sarah K.; Zofkie, Amanda C.; Nelson, David B.

In: Obstetrics and Gynecology, Vol. 128, No. 6, 01.12.2016, p. 1437-1440.

Research output: Contribution to journalArticle

Happe, Sarah K. ; Zofkie, Amanda C. ; Nelson, David B. / Microangiopathic Hemolytic Anemia Due to Malignancy in Pregnancy. In: Obstetrics and Gynecology. 2016 ; Vol. 128, No. 6. pp. 1437-1440.
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