Microangiopathies in pregnancy

Jailan Elayoubi, Kavitha Donthireddy, DIvyesh Reddy Nemakayala

Research output: Contribution to journalArticle

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a potentially reversible, life-threatening medical emergency. We present a case of a 21-year-old female with evidence of haemolytic anaemia based on the presence of positive markers of haemolysis. Negative Coomb's test, thrombocytopenia and placental infarcts raised suspicion for a thrombotic microangiopathy. She was diagnosed with TTP and managed with emergency plasma exchange. Her recovery was immediate. A presumptive diagnosis of TTP should be based on the presence of microangiopathic haemolytic anaemia with thrombocytopenia and plasma exchange should be initiated while complete work up is pending. Using the regular pentad solely for diagnosis of TTP will lead to underdiagnosis of many cases and should be avoided. Several microangiopathies can be seen during pregnancy including TTP/atypical haemolytic uraemic syndrome, HELLP syndrome, pre-eclampsia, disseminated intravascular coagulopathy and antiphospholipid antibody syndrome. Distinction between each type will be the focus of our discussion as treatment decisions differ accordingly.

Original languageEnglish (US)
Article number3695
JournalBMJ Case Reports
Volume2018
DOIs
StatePublished - Jan 1 2018

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Thrombotic Thrombocytopenic Purpura
Pregnancy
Plasma Exchange
Hemolytic Anemia
Thrombocytopenia
Emergencies
HELLP Syndrome
Thrombotic Microangiopathies
Coombs Test
Antiphospholipid Syndrome
Hemolysis
Pre-Eclampsia

Keywords

  • Malignant And Benign Haematology
  • Pregnancy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Microangiopathies in pregnancy. / Elayoubi, Jailan; Donthireddy, Kavitha; Nemakayala, DIvyesh Reddy.

In: BMJ Case Reports, Vol. 2018, 3695, 01.01.2018.

Research output: Contribution to journalArticle

Elayoubi, Jailan ; Donthireddy, Kavitha ; Nemakayala, DIvyesh Reddy. / Microangiopathies in pregnancy. In: BMJ Case Reports. 2018 ; Vol. 2018.
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