Microbiologic and immunologic evaluation of a single high dose of azithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia

Ana María Ríos, Mónica Fonseca-Aten, Asunción Mejías, Susana Chávez-Bueno, Kathy Katz, Ana María Gómez, George H. McCracken, Octavio Ramilo, R. Doug Hardy

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Abstract

We evaluated the efficacy of azithromycin therapy given as a single high dose or divided over 5 days for the treatment of mild experimental Mycoplasma pneumoniae pneumonia. Although both azithromycin regimens significantly reduced quantitative cultures, lung histopathology, and pulmonary cytokines and chemokines, there were no significant differences between the two regimens.

Original languageEnglish (US)
Pages (from-to)3970-3973
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number9
DOIs
Publication statusPublished - Sep 2005

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ASJC Scopus subject areas

  • Pharmacology (medical)

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