Microcytosis associated with sickle cell anemia

B. E. Glader; R. D. Propper; G. R. Buchanan

doi:10.1093/ajcp/72.1.63

Microcytosis associated with sickle cell anemia

B. E. Glader, R. D. Propper, G. R. Buchanan

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 ± 2.4 μμg and mean corpuscular volume (MCV) was 88.1 ± 6.8 cu μm. In contrast, patients in a comparable hemolytic-disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 ± 1.8 μμg) and larger MCV (97 ± 5.3 cu μm). These data indicate that Hb SS disease is associated with 'relative microcytosis', presumably a consequence of reduced hemoglobin production.

Original language	English (US)
Pages (from-to)	63-64
Number of pages	2
Journal	American journal of clinical pathology
Volume	72
Issue number	1
DOIs	https://doi.org/10.1093/ajcp/72.1.63
State	Published - 1979

ASJC Scopus subject areas

Pathology and Forensic Medicine

Access to Document

10.1093/ajcp/72.1.63

Cite this

@article{2babbd6a84e94e22aea7ce83733a8780,

title = "Microcytosis associated with sickle cell anemia",

abstract = "Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 ± 2.4 μμg and mean corpuscular volume (MCV) was 88.1 ± 6.8 cu μm. In contrast, patients in a comparable hemolytic-disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 ± 1.8 μμg) and larger MCV (97 ± 5.3 cu μm). These data indicate that Hb SS disease is associated with 'relative microcytosis', presumably a consequence of reduced hemoglobin production.",

author = "Glader, {B. E.} and Propper, {R. D.} and Buchanan, {G. R.}",

year = "1979",

doi = "10.1093/ajcp/72.1.63",

language = "English (US)",

volume = "72",

pages = "63--64",

journal = "American journal of clinical pathology",

issn = "0002-9173",

publisher = "American Society of Clinical Pathologists",

number = "1",

}

TY - JOUR

T1 - Microcytosis associated with sickle cell anemia

AU - Glader, B. E.

AU - Propper, R. D.

AU - Buchanan, G. R.

PY - 1979

Y1 - 1979

N2 - Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 ± 2.4 μμg and mean corpuscular volume (MCV) was 88.1 ± 6.8 cu μm. In contrast, patients in a comparable hemolytic-disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 ± 1.8 μμg) and larger MCV (97 ± 5.3 cu μm). These data indicate that Hb SS disease is associated with 'relative microcytosis', presumably a consequence of reduced hemoglobin production.

AB - Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 ± 2.4 μμg and mean corpuscular volume (MCV) was 88.1 ± 6.8 cu μm. In contrast, patients in a comparable hemolytic-disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 ± 1.8 μμg) and larger MCV (97 ± 5.3 cu μm). These data indicate that Hb SS disease is associated with 'relative microcytosis', presumably a consequence of reduced hemoglobin production.

UR - http://www.scopus.com/inward/record.url?scp=0018778746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018778746&partnerID=8YFLogxK

U2 - 10.1093/ajcp/72.1.63

DO - 10.1093/ajcp/72.1.63

M3 - Article

C2 - 453112

AN - SCOPUS:0018778746

SN - 0002-9173

VL - 72

SP - 63

EP - 64

JO - American journal of clinical pathology

JF - American journal of clinical pathology

IS - 1

ER -

Microcytosis associated with sickle cell anemia

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this