Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 ± 2.4 μμg and mean corpuscular volume (MCV) was 88.1 ± 6.8 cu μm. In contrast, patients in a comparable hemolytic-disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 ± 1.8 μμg) and larger MCV (97 ± 5.3 cu μm). These data indicate that Hb SS disease is associated with 'relative microcytosis', presumably a consequence of reduced hemoglobin production.
ASJC Scopus subject areas
- Pathology and Forensic Medicine