Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effectsin vivo

Michelle D. Combs, Russell H. Knutsen, Thomas J. Broekelmann, Holly M. Toennies, Thomas J. Brett, Chantel A. Miller, Daniel L. Kober, Clarissa S. Craft, Jeffrey J. Atkinson, J. Michael Shipley, Barbara C. Trask, Robert P. Mecham

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Background:The function of MAGP2 was studied by inactivating its gene (Mfap5-/-) in mice. Results:Mfap5-/- mice have a neutrophil deficiency and other phenotypes that are different from MAGP1- and fibrillindeficient animals. Conclusion:MAGP2 has functional roles in hematopoiesis and in vessel wall maintenance. Significance:Characterization of MAGP2 function is crucial to the identification and treatment of microfibril-related disease.

Original languageEnglish (US)
Pages (from-to)28869-28880
Number of pages12
JournalJournal of Biological Chemistry
Issue number40
StatePublished - Oct 4 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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