Microglial TLR9: Guardians of homeostatic hippocampal neurogenesis

Kyung Ok Cho, Jenny Hsieh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pathological conditions such as epilepsy cause misregulation of adult neural stem/progenitor populations in the adult hippocampus in mice, and the resulting abnormal neurogenesis leads to impairment in learning and memory. However, how animals cope with abnormal neurogenesis remains unknown. Here we show that microglia in the mouse hippocampus attenuate convulsive seizure-mediated aberrant neurogenesis through the activation of Toll-like receptor 9 (TLR9), an innate immune sensor known to recognize microbial DNA and trigger inflammatory responses. We found that microglia sense self-DNA from degenerating neurons following seizure, and secrete tumour necrosis factor-α, resulting in attenuation of aberrant neurogenesis. Furthermore, TLR9 deficiency exacerbated seizure-induced cognitive decline and recurrent seizure severity. Our findings thus suggest the existence of bidirectional communication between the innate immune and nervous systems for the maintenance of adult brain integrity.

Original languageEnglish (US)
Pages (from-to)39-40
Number of pages2
JournalEpilepsy Currents
Volume16
Issue number1
StatePublished - 2016

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Toll-Like Receptor 9
Neurogenesis
Seizures
Microglia
Hippocampus
DNA
Nervous System
Immune System
Epilepsy
Tumor Necrosis Factor-alpha
Communication
Maintenance
Learning
Neurons
Brain
Population

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Microglial TLR9 : Guardians of homeostatic hippocampal neurogenesis. / Cho, Kyung Ok; Hsieh, Jenny.

In: Epilepsy Currents, Vol. 16, No. 1, 2016, p. 39-40.

Research output: Contribution to journalArticle

Cho, KO & Hsieh, J 2016, 'Microglial TLR9: Guardians of homeostatic hippocampal neurogenesis', Epilepsy Currents, vol. 16, no. 1, pp. 39-40.
Cho, Kyung Ok ; Hsieh, Jenny. / Microglial TLR9 : Guardians of homeostatic hippocampal neurogenesis. In: Epilepsy Currents. 2016 ; Vol. 16, No. 1. pp. 39-40.
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