Microneurographic study of C fiber discharges induced by CO2 laser stimulation in humans

Yunhai Qiu, Qi Fu, Xiaohong Wang, Tuan Diep Tran, Koji Inui, Satoshi Iwase, Ryusuke Kakigi

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


We investigated C-fiber discharges and cerebral potentials evoked by weak CO2 laser beams applied to a tiny skin area in five healthy subjects. Microneurography was performed from the peroneal nerve in the right popliteal area. Cerebral potentials were recorded from the Cz electrode referred to linked earlobes. The mean conduction velocity of five stable single units was 1.1±0.3 m/s. The mean latency of the positive peak of cerebral potentials was 1327.4±46.2 ms. These findings indicated that this new stimulation method selectively activated C-fiber nociceptors of the skin.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalNeuroscience letters
Issue number1
StatePublished - Dec 15 2003


  • C-fibers
  • CO laser
  • Conduction velocity
  • Electroencephalogram
  • Laser evoked potentials
  • Microelectroneurography
  • Pain

ASJC Scopus subject areas

  • Neuroscience(all)


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