MicroPET: A high resolution PET scanner for imaging small animals

S. R. Cherry; Y. Shao; S. Siegel; R. W. Silverman; K. Meadors; J. Young; W. F. Jones; D. Newport; C. Moyers; E. U. Mumcuoglu; A. Chatziioannou; T. Farquhar; M. Andreaco; M. Paulus; D. Binkley

MicroPET: A high resolution PET scanner for imaging small animals

S. R. Cherry, Y. Shao, S. Siegel, R. W. Silverman, K. Meadors, J. Young, W. F. Jones, D. Newport, C. Moyers, E. U. Mumcuoglu, A. Chatziioannou, T. Farquhar, M. Andreaco, M. Paulus, D. Binkley

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Scopus citations

Abstract

MicroPET is a high resolution positron emission tomography (PET) scanner designed for imaging small laboratory animals. It consists of a ring of 30 position-sensitive scintillation detectors, each with an 8×8 array of small lutetium oxyorthosilicate (LSO) crystals coupled via optical fibers to a multi-channel photomultiplier tube. The detectors have an intrinsic resolution averaging 1.68 mm, an energy resolution between 15 and 25% and 2.4 ns timing resolution at 511 keV. The detector ring diameter of microPET is 17.2 cm with an imaging field of view of 112 mm transaxially by 18 mm axially. The scanner has no septa and operates exclusively in 3D mode. Reconstructed image resolution 1 cm from the center of the scanner is 2.0 mm and virtually isotropic, yielding a volume resolution of 8 mm³. For comparison, the volume resolution of state-of-the-art clinical PET systems is in the range of 50-75 mm³. Initial images of phantoms have been acquired and are reported. A computer controlled bed is under construction and will incorporate a small wobble motion to improve spatial sampling. This is projected to further enhance spatial resolution. MicroPET is the first PET scanner to incorporate the new scintillator LSO and to our knowledge is the highest resolution multi-ring PET scanner currently in existence.

Original language	English (US)
Title of host publication	IEEE Nuclear Science Symposium & Medical Imaging Conference
Publisher	IEEE
Pages	1120-1124
Number of pages	5
Volume	2
State	Published - Dec 1 1996
Event	Proceedings of the 1996 IEEE Nuclear Science Symposium. Part 1 (of 3) - Anaheim, CA, USA Duration: Nov 2 1996 → Nov 9 1996

Other

Other	Proceedings of the 1996 IEEE Nuclear Science Symposium. Part 1 (of 3)
City	Anaheim, CA, USA
Period	11/2/96 → 11/9/96

ASJC Scopus subject areas

Computer Vision and Pattern Recognition
Industrial and Manufacturing Engineering

Cite this

Cherry, S. R., Shao, Y., Siegel, S., Silverman, R. W., Meadors, K., Young, J., Jones, W. F., Newport, D., Moyers, C., Mumcuoglu, E. U., Chatziioannou, A., Farquhar, T., Andreaco, M., Paulus, M., & Binkley, D. (1996). MicroPET: A high resolution PET scanner for imaging small animals. In IEEE Nuclear Science Symposium & Medical Imaging Conference (Vol. 2, pp. 1120-1124). IEEE.

Cherry, SR, Shao, Y, Siegel, S, Silverman, RW, Meadors, K, Young, J, Jones, WF, Newport, D, Moyers, C, Mumcuoglu, EU, Chatziioannou, A, Farquhar, T, Andreaco, M, Paulus, M & Binkley, D 1996, MicroPET: A high resolution PET scanner for imaging small animals. in IEEE Nuclear Science Symposium & Medical Imaging Conference. vol. 2, IEEE, pp. 1120-1124, Proceedings of the 1996 IEEE Nuclear Science Symposium. Part 1 (of 3), Anaheim, CA, USA, 11/2/96.

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title = "MicroPET: A high resolution PET scanner for imaging small animals",

abstract = "MicroPET is a high resolution positron emission tomography (PET) scanner designed for imaging small laboratory animals. It consists of a ring of 30 position-sensitive scintillation detectors, each with an 8×8 array of small lutetium oxyorthosilicate (LSO) crystals coupled via optical fibers to a multi-channel photomultiplier tube. The detectors have an intrinsic resolution averaging 1.68 mm, an energy resolution between 15 and 25% and 2.4 ns timing resolution at 511 keV. The detector ring diameter of microPET is 17.2 cm with an imaging field of view of 112 mm transaxially by 18 mm axially. The scanner has no septa and operates exclusively in 3D mode. Reconstructed image resolution 1 cm from the center of the scanner is 2.0 mm and virtually isotropic, yielding a volume resolution of 8 mm3. For comparison, the volume resolution of state-of-the-art clinical PET systems is in the range of 50-75 mm3. Initial images of phantoms have been acquired and are reported. A computer controlled bed is under construction and will incorporate a small wobble motion to improve spatial sampling. This is projected to further enhance spatial resolution. MicroPET is the first PET scanner to incorporate the new scintillator LSO and to our knowledge is the highest resolution multi-ring PET scanner currently in existence.",

author = "Cherry, {S. R.} and Y. Shao and S. Siegel and Silverman, {R. W.} and K. Meadors and J. Young and Jones, {W. F.} and D. Newport and C. Moyers and Mumcuoglu, {E. U.} and A. Chatziioannou and T. Farquhar and M. Andreaco and M. Paulus and D. Binkley",

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AU - Cherry, S. R.

AU - Shao, Y.

AU - Siegel, S.

AU - Silverman, R. W.

AU - Meadors, K.

AU - Young, J.

AU - Jones, W. F.

AU - Newport, D.

AU - Moyers, C.

AU - Mumcuoglu, E. U.

AU - Chatziioannou, A.

AU - Farquhar, T.

AU - Andreaco, M.

AU - Paulus, M.

AU - Binkley, D.

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N2 - MicroPET is a high resolution positron emission tomography (PET) scanner designed for imaging small laboratory animals. It consists of a ring of 30 position-sensitive scintillation detectors, each with an 8×8 array of small lutetium oxyorthosilicate (LSO) crystals coupled via optical fibers to a multi-channel photomultiplier tube. The detectors have an intrinsic resolution averaging 1.68 mm, an energy resolution between 15 and 25% and 2.4 ns timing resolution at 511 keV. The detector ring diameter of microPET is 17.2 cm with an imaging field of view of 112 mm transaxially by 18 mm axially. The scanner has no septa and operates exclusively in 3D mode. Reconstructed image resolution 1 cm from the center of the scanner is 2.0 mm and virtually isotropic, yielding a volume resolution of 8 mm3. For comparison, the volume resolution of state-of-the-art clinical PET systems is in the range of 50-75 mm3. Initial images of phantoms have been acquired and are reported. A computer controlled bed is under construction and will incorporate a small wobble motion to improve spatial sampling. This is projected to further enhance spatial resolution. MicroPET is the first PET scanner to incorporate the new scintillator LSO and to our knowledge is the highest resolution multi-ring PET scanner currently in existence.

AB - MicroPET is a high resolution positron emission tomography (PET) scanner designed for imaging small laboratory animals. It consists of a ring of 30 position-sensitive scintillation detectors, each with an 8×8 array of small lutetium oxyorthosilicate (LSO) crystals coupled via optical fibers to a multi-channel photomultiplier tube. The detectors have an intrinsic resolution averaging 1.68 mm, an energy resolution between 15 and 25% and 2.4 ns timing resolution at 511 keV. The detector ring diameter of microPET is 17.2 cm with an imaging field of view of 112 mm transaxially by 18 mm axially. The scanner has no septa and operates exclusively in 3D mode. Reconstructed image resolution 1 cm from the center of the scanner is 2.0 mm and virtually isotropic, yielding a volume resolution of 8 mm3. For comparison, the volume resolution of state-of-the-art clinical PET systems is in the range of 50-75 mm3. Initial images of phantoms have been acquired and are reported. A computer controlled bed is under construction and will incorporate a small wobble motion to improve spatial sampling. This is projected to further enhance spatial resolution. MicroPET is the first PET scanner to incorporate the new scintillator LSO and to our knowledge is the highest resolution multi-ring PET scanner currently in existence.

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ER -

MicroPET: A high resolution PET scanner for imaging small animals

Abstract

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