MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion

Jessica Bockhorn, Kathy Yee, Ya Fang Chang, Aleix Prat, Dezheng Huo, Chika Nwachukwu, Rachel Dalton, Simo Huang, Kaitlin E. Swanson, Charles M. Perou, Olufunmilayo I. Olopade, Michael F. Clarke, Geoffrey L. Greene, Huiping Liu

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Metastasis remains a significant challenge in treating cancer. A better understanding of the molecular mechanisms underlying metastasis is needed to develop more effective treatments. Here, we show that human breast tumor biomarker miR-30c regulates invasion by targeting the cytoskeleton network genes encoding twinfilin 1 (TWF1) and vimentin (VIM). Both VIM and TWF1 have been shown to regulate epithelial-to-mesenchymal transition. Similar to TWF1, VIM also regulates F-actin formation, a key component of cellular transition to a more invasive mesenchymal phenotype. To further characterize the role of the TWF1 pathway in breast cancer, we found that IL-11 is an important target of TWF1 that regulates breast cancer cell invasion and STAT3 phosphorylation. The miR-30c-VIM/TWF1 signaling cascade is also associated with clinical outcome in breast cancer patients.

Original languageEnglish (US)
Pages (from-to)373-382
Number of pages10
JournalBreast Cancer Research and Treatment
Volume137
Issue number2
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Vimentin
Cytoskeleton
MicroRNAs
Breast Neoplasms
Genes
Interleukin-11
Neoplasm Metastasis
Epithelial-Mesenchymal Transition
Gene Regulatory Networks
Tumor Biomarkers
Actins
Phosphorylation
Phenotype
Neoplasms
Therapeutics

Keywords

  • Breast tumor invasion
  • IL-11
  • miR-30c
  • TWF1
  • VIM

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. / Bockhorn, Jessica; Yee, Kathy; Chang, Ya Fang; Prat, Aleix; Huo, Dezheng; Nwachukwu, Chika; Dalton, Rachel; Huang, Simo; Swanson, Kaitlin E.; Perou, Charles M.; Olopade, Olufunmilayo I.; Clarke, Michael F.; Greene, Geoffrey L.; Liu, Huiping.

In: Breast Cancer Research and Treatment, Vol. 137, No. 2, 01.01.2013, p. 373-382.

Research output: Contribution to journalArticle

Bockhorn, J, Yee, K, Chang, YF, Prat, A, Huo, D, Nwachukwu, C, Dalton, R, Huang, S, Swanson, KE, Perou, CM, Olopade, OI, Clarke, MF, Greene, GL & Liu, H 2013, 'MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion', Breast Cancer Research and Treatment, vol. 137, no. 2, pp. 373-382. https://doi.org/10.1007/s10549-012-2346-4
Bockhorn, Jessica ; Yee, Kathy ; Chang, Ya Fang ; Prat, Aleix ; Huo, Dezheng ; Nwachukwu, Chika ; Dalton, Rachel ; Huang, Simo ; Swanson, Kaitlin E. ; Perou, Charles M. ; Olopade, Olufunmilayo I. ; Clarke, Michael F. ; Greene, Geoffrey L. ; Liu, Huiping. / MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. In: Breast Cancer Research and Treatment. 2013 ; Vol. 137, No. 2. pp. 373-382.
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