MicroRNA control of muscle development and disease

Andrew H. Williams, Ning Liu, Eva van Rooij, Eric N. Olson

Research output: Contribution to journalReview article

245 Scopus citations

Abstract

Cardiac and skeletal muscle development are controlled by evolutionarily conserved networks of transcription factors that coordinate the expression of genes involved in muscle growth, morphogenesis, differentiation, and contractility. In addition to regulating the expression of protein-coding genes, recent studies have revealed that myogenic transcription factors control the expression of a collection of microRNAs, which act through multiple mechanisms to modulate muscle development and function. In some cases, microRNAs fine-tune the expression of target mRNAs, whereas in other cases they function as 'on-off' switches. MicroRNA control of gene expression appears to be especially important during cardiovascular and skeletal muscle diseases, in which microRNAs participate in stress-dependent remodeling of striated muscle tissues. We review findings that point to the importance of microRNA-mediated control of gene expression during muscle development and disease, and consider the potential of microRNAs as therapeutic targets.

Original languageEnglish (US)
Pages (from-to)461-469
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume21
Issue number3
DOIs
StatePublished - Jun 1 2009

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ASJC Scopus subject areas

  • Cell Biology

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