TY - JOUR
T1 - MicroRNA control of muscle development and disease
AU - Williams, Andrew H.
AU - Liu, Ning
AU - van Rooij, Eva
AU - Olson, Eric N.
N1 - Funding Information:
We apologize to the many researchers whose work was not cited in this review owing to space limitations. We thank Jose Cabrera for graphics and Jennifer Brown for editorial assistance. Work in the laboratory of ENO is supported by grants from the NIH, the Donald W Reynolds Center for Clinical Cardiovascular Research, the Leducq Foundation, the Sandler Foundation for Asthma Research, and the Robert A Welch Foundation. AHW is supported by a training grant from the National Heart, Lung, and Blood Institute (T32HL007360). NL and EvR were supported by grants from the American Heart Association.
PY - 2009/6
Y1 - 2009/6
N2 - Cardiac and skeletal muscle development are controlled by evolutionarily conserved networks of transcription factors that coordinate the expression of genes involved in muscle growth, morphogenesis, differentiation, and contractility. In addition to regulating the expression of protein-coding genes, recent studies have revealed that myogenic transcription factors control the expression of a collection of microRNAs, which act through multiple mechanisms to modulate muscle development and function. In some cases, microRNAs fine-tune the expression of target mRNAs, whereas in other cases they function as 'on-off' switches. MicroRNA control of gene expression appears to be especially important during cardiovascular and skeletal muscle diseases, in which microRNAs participate in stress-dependent remodeling of striated muscle tissues. We review findings that point to the importance of microRNA-mediated control of gene expression during muscle development and disease, and consider the potential of microRNAs as therapeutic targets.
AB - Cardiac and skeletal muscle development are controlled by evolutionarily conserved networks of transcription factors that coordinate the expression of genes involved in muscle growth, morphogenesis, differentiation, and contractility. In addition to regulating the expression of protein-coding genes, recent studies have revealed that myogenic transcription factors control the expression of a collection of microRNAs, which act through multiple mechanisms to modulate muscle development and function. In some cases, microRNAs fine-tune the expression of target mRNAs, whereas in other cases they function as 'on-off' switches. MicroRNA control of gene expression appears to be especially important during cardiovascular and skeletal muscle diseases, in which microRNAs participate in stress-dependent remodeling of striated muscle tissues. We review findings that point to the importance of microRNA-mediated control of gene expression during muscle development and disease, and consider the potential of microRNAs as therapeutic targets.
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U2 - 10.1016/j.ceb.2009.01.029
DO - 10.1016/j.ceb.2009.01.029
M3 - Review article
C2 - 19278845
AN - SCOPUS:66049132154
SN - 0955-0674
VL - 21
SP - 461
EP - 469
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -