MicroRNA Regulatory Networks in Cardiovascular Development

Research output: Contribution to journalArticle

332 Citations (Scopus)

Abstract

The heart, more than any other organ, requires precise functionality on a second-to-second basis throughout the lifespan of the organism. Even subtle perturbations in cardiac structure or function have catastrophic consequences, resulting in lethal forms of congenital and adult heart disease. Such intolerance of the heart to variability necessitates especially robust regulatory mechanisms to govern cardiac gene expression. Recent studies have revealed central roles for microRNAs (miRNAs) as governors of gene expression during cardiovascular development and disease. The integration of miRNAs into the genetic circuitry of the heart provides a rich and robust array of regulatory interactions to control cardiac gene expression. miRNA regulatory networks also offer opportunities for therapeutically modulating cardiac function through the manipulation of pathogenic and protective miRNAs. We discuss the roles of miRNAs as regulators of cardiac form and function, unresolved questions in the field, and issues for the future.

Original languageEnglish (US)
Pages (from-to)510-525
Number of pages16
JournalDevelopmental Cell
Volume18
Issue number4
DOIs
StatePublished - Apr 2010

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MicroRNAs
Gene expression
Gene Expression
Governors
Heart Diseases
Cardiovascular Diseases

ASJC Scopus subject areas

  • Developmental Biology

Cite this

MicroRNA Regulatory Networks in Cardiovascular Development. / Liu, Ning; Olson, Eric N.

In: Developmental Cell, Vol. 18, No. 4, 04.2010, p. 510-525.

Research output: Contribution to journalArticle

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