MicroRNA: Relevance to stroke diagnosis, prognosis, and therapy

Hamed Mirzaei, Fatemeh Momeni, Leila Saadatpour, Amirhossein Sahebkar, Mohammad Goodarzi, Aria Masoudifar, Shirin Kouhpayeh, Hossein Salehi, Hamid Reza Mirzaei, Mahmoud Reza Jaafari

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations

Abstract

Stroke is a life-threatening disease that accounts for a considerable burden of mortality in both developing and developed world. Identification of specific biomarkers for stroke and its outcomes can greatly contribute to improved care of patients. MicroRNAs (miRNAs) are known as novel biomarkers that could be used as diagnostic, prognostic, and therapeutic biomarkers. Various studies have shown that miRNAs have key roles in the pathogenesis of stroke, and its complications and outcomes. In addition, there is evidence showing that mesenchaymal stromal cell-derived exosomes containing miRNAs can be used for monitoring and treatment of various diseases such as stroke. Here, we summarized various aspects of miRNA applications in different stages of stroke.

Original languageEnglish (US)
Pages (from-to)856-865
Number of pages10
JournalJournal of cellular physiology
Volume233
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • biomarker
  • exosome
  • meseanchaymal stromal cell
  • microRNA
  • stroke

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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