MicroRNA therapeutics for cardiovascular disease: Opportunities and obstacles

Eva Van Rooij, Eric N. Olson

Research output: Contribution to journalReview article

411 Scopus citations

Abstract

In recent years, prominent roles for microRNAs (miRNAs) have been uncovered in several cardiovascular disorders. The ability to therapeutically manipulate miRNA expression and function through systemic or local delivery of miRNA inhibitors, referred to as antimiRs, has triggered enthusiasm for miRNAs as novel therapeutic targets. Here, we focus on the pharmacokinetic and pharmacodynamic properties of current antimiR designs and their relevance to cardiovascular indications, and evaluate the opportunities and obstacles associated with this new therapeutic modality.

Original languageEnglish (US)
Pages (from-to)860-872
Number of pages13
JournalNature Reviews Drug Discovery
Volume11
Issue number11
DOIs
StatePublished - Nov 1 2012

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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