MicroRNAs in cardiovascular disease: From pathogenesis to prevention and treatment

Daniel Quiat, Eric N. Olson

Research output: Contribution to journalReview article

172 Scopus citations

Abstract

The management of cardiovascular risk through lifestyle modification and pharmacotherapy is paramount to the prevention of cardiovascular disease. Epidemiological studies have identified obesity, dyslipidemia, diabetes, and hypertension as interrelated factors that negatively affect cardiovascular health. Recently, genetic and pharmacological evidence in model systems has implicated microRNAs as dynamic modifiers of disease pathogenesis. An expanded understanding of the function of microRNAs in gene regulatory networks associated with cardiovascular risk will enable identification of novel genetic mechanisms of disease and inform the development of innovative therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalJournal of Clinical Investigation
Volume123
Issue number1
DOIs
StatePublished - Jan 2 2013

ASJC Scopus subject areas

  • Medicine(all)

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