MicroRNAs in Platelet Production and Activation

Leonard C. Edelstein, Srikanth Nagalla, Paul F. Bray

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

MicroRNAs are small RNA molecules that modulate protein expression by degrading mRNA or repressing translation. They have been shown to play important roles in hematopoiesis, including embryonic stem cell differentiation, erythropoiesis, granulocytopoiesis/monocytopoiesis, lymphopoiesis, and megakaryocytopoiesis. miR-150 and miR-155 play divergent roles in megakaryocytopoiesis with the former promoting development of megakaryocytes at the expense of erythrocytes and the latter causing a reduction in megakaryocyte colony formation. Platelets also contain fully functional miRNA machinery, and certain miRNA levels in platelets have been found to correlate with reactivity to specific agonists and to pathological states. This review will cover the current state of knowledge of miRNAs in megakaryocytes and platelets and the exciting possibilities for future research.

Original languageEnglish (US)
Title of host publicationMicroRNAs in Medicine
PublisherWiley Blackwell
Pages101-116
Number of pages16
ISBN (Electronic)9781118300312
ISBN (Print)9781118300398
DOIs
StatePublished - Nov 4 2013

Keywords

  • Biomarkers
  • Megakaryocytes
  • Megakaryopoiesis
  • Microparticles
  • MicroRNA
  • Platelets

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Edelstein, L. C., Nagalla, S., & Bray, P. F. (2013). MicroRNAs in Platelet Production and Activation. In MicroRNAs in Medicine (pp. 101-116). Wiley Blackwell. https://doi.org/10.1002/9781118300312.ch7