MicroRNAs in stress signaling and human disease

Research output: Contribution to journalArticle

956 Citations (Scopus)

Abstract

Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics.

Original languageEnglish (US)
Pages (from-to)1172-1187
Number of pages16
JournalCell
Volume148
Issue number6
DOIs
StatePublished - Mar 16 2012

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MicroRNAs
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RNA
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

MicroRNAs in stress signaling and human disease. / Mendell, Joshua T.; Olson, Eric N.

In: Cell, Vol. 148, No. 6, 16.03.2012, p. 1172-1187.

Research output: Contribution to journalArticle

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