MicroRNAs

Powerful new regulators of heart disease and provocative therapeutic targets

Eva Van Rooij, Eric N. Olson

Research output: Contribution to journalArticle

379 Citations (Scopus)

Abstract

MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

Original languageEnglish (US)
Pages (from-to)2369-2376
Number of pages8
JournalJournal of Clinical Investigation
Volume117
Issue number9
DOIs
StatePublished - Sep 4 2007

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MicroRNAs
Heart Diseases
RNA Stability
Regulator Genes
Growth and Development
Gene Expression
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

MicroRNAs : Powerful new regulators of heart disease and provocative therapeutic targets. / Van Rooij, Eva; Olson, Eric N.

In: Journal of Clinical Investigation, Vol. 117, No. 9, 04.09.2007, p. 2369-2376.

Research output: Contribution to journalArticle

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